Bibliographic Details
| Title: |
Susceptibilidad genética al síndrome metabólico: una mirada comparativa entre México y el mundo. |
| Alternate Title: |
Genetic Susceptibility to Metabolic Syndrome: A Comparative Overview of the Mexican Population in a Global Context. |
| Authors: |
Arturo Gallardo-Hernández, Carlos1 argallardo@uv.mx, Díaz-Alberto, Jaqueline2, Antonio Palma-Jacinto, José2, Montero-Ruíz, Oreth3, Ramírez-Franco, Ulises4 |
| Source: |
Revista Medica del IMSS. jul/ago2026, Vol. 64 Issue 4, p1-10. 10p. |
| Subjects: |
Metabolic syndrome, Population genetics, Comparative studies, Regulation of blood pressure, Glucose metabolism, Genetic risk score, Mexicans, Lipid metabolism |
| Geographic Terms: |
Mexico |
| Abstract (English): |
Metabolic syndrome (MetS) is a multifactorial condition involving environmental factors, lifestyle behaviors, and genetic variants. The objective of this review was to analyze and compare the available evidence on genetic susceptibility to MetS in the Mexican population and in other regions of the world, in order to identify convergences and population-specific features. A narrative review of the scientific literature published between 2020 and 2025 was conducted using international databases. The methodological quality and scientific relevance of the studies were assessed using criteria adapted from the Q-Genie instrument. The results show that genetic variants involved in glucose and lipid metabolism, as well as in blood pressure regulation, are associated with MetS across diverse populations. However, relevant differences were identified in the frequency and phenotypic effects of these variants between the Mexican population and other regions worldwide. In conclusion, the evidence suggests that genetic susceptibility to MetS exhibits a population-specific component in Mexico. In this context, further investigation of genetic variants associated with MetS is warranted to contribute to the strengthening of preventive strategies aimed at reducing the burden of MetS in the Mexican population. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): |
El síndrome metabólico (SM) es una condición multifactorial en la que participan factores ambientales, estilos de vida y variantes genéticas. El objetivo de esta revisión fue analizar y comparar la evidencia disponible sobre la susceptibilidad genética al SM en la población mexicana y en otras regiones del mundo, con el fin de identificar convergencias y particularidades poblacionales. Se realizó una revisión narrativa de la literatura científica publicada entre 2020 y 2025 en bases de datos internacionales. La calidad metodológica y la pertinencia científica de los estudios se evaluaron por medio de criterios adaptados del instrumento Q-Genie. Los resultados muestran que variantes genéticas involucradas en el metabolismo de la glucosa, los lípidos y la regulación de la presión arterial se asocian con el SM en diversas poblaciones. Sin embargo, se identificaron diferencias relevantes en la frecuencia y el efecto fenotípico de estas variantes entre la población mexicana y otras regiones del mundo. En conclusión, la evidencia sugiere que la susceptibilidad genética al SM presenta un componente poblacional específico en México. En este sentido, resulta necesario profundizar en el estudio de las variantes genéticas asociadas al SM para coadyuvar en el fortalecimiento de estrategias preventivas orientadas a reducir la carga del SM en la población mexicana. [ABSTRACT FROM AUTHOR] |
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| Database: |
MedicLatina |
