Susceptibilidad genética al síndrome metabólico: una mirada comparativa entre México y el mundo.
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| Title: | Susceptibilidad genética al síndrome metabólico: una mirada comparativa entre México y el mundo. |
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| Alternate Title: | Genetic Susceptibility to Metabolic Syndrome: A Comparative Overview of the Mexican Population in a Global Context. |
| Authors: | Arturo Gallardo-Hernández, Carlos1 argallardo@uv.mx, Díaz-Alberto, Jaqueline2, Antonio Palma-Jacinto, José2, Montero-Ruíz, Oreth3, Ramírez-Franco, Ulises4 |
| Source: | Revista Medica del IMSS. jul/ago2026, Vol. 64 Issue 4, p1-10. 10p. |
| Subjects: | Metabolic syndrome, Population genetics, Comparative studies, Regulation of blood pressure, Glucose metabolism, Genetic risk score, Mexicans, Lipid metabolism |
| Geographic Terms: | Mexico |
| Abstract (English): | Metabolic syndrome (MetS) is a multifactorial condition involving environmental factors, lifestyle behaviors, and genetic variants. The objective of this review was to analyze and compare the available evidence on genetic susceptibility to MetS in the Mexican population and in other regions of the world, in order to identify convergences and population-specific features. A narrative review of the scientific literature published between 2020 and 2025 was conducted using international databases. The methodological quality and scientific relevance of the studies were assessed using criteria adapted from the Q-Genie instrument. The results show that genetic variants involved in glucose and lipid metabolism, as well as in blood pressure regulation, are associated with MetS across diverse populations. However, relevant differences were identified in the frequency and phenotypic effects of these variants between the Mexican population and other regions worldwide. In conclusion, the evidence suggests that genetic susceptibility to MetS exhibits a population-specific component in Mexico. In this context, further investigation of genetic variants associated with MetS is warranted to contribute to the strengthening of preventive strategies aimed at reducing the burden of MetS in the Mexican population. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | El síndrome metabólico (SM) es una condición multifactorial en la que participan factores ambientales, estilos de vida y variantes genéticas. El objetivo de esta revisión fue analizar y comparar la evidencia disponible sobre la susceptibilidad genética al SM en la población mexicana y en otras regiones del mundo, con el fin de identificar convergencias y particularidades poblacionales. Se realizó una revisión narrativa de la literatura científica publicada entre 2020 y 2025 en bases de datos internacionales. La calidad metodológica y la pertinencia científica de los estudios se evaluaron por medio de criterios adaptados del instrumento Q-Genie. Los resultados muestran que variantes genéticas involucradas en el metabolismo de la glucosa, los lípidos y la regulación de la presión arterial se asocian con el SM en diversas poblaciones. Sin embargo, se identificaron diferencias relevantes en la frecuencia y el efecto fenotípico de estas variantes entre la población mexicana y otras regiones del mundo. En conclusión, la evidencia sugiere que la susceptibilidad genética al SM presenta un componente poblacional específico en México. En este sentido, resulta necesario profundizar en el estudio de las variantes genéticas asociadas al SM para coadyuvar en el fortalecimiento de estrategias preventivas orientadas a reducir la carga del SM en la población mexicana. [ABSTRACT FROM AUTHOR] |
| Copyright of Revista Medica del IMSS is the property of Direccion de Prestaciones Medicas - IMSS and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
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| Header | DbId: lth DbLabel: MedicLatina An: 195890365 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Susceptibilidad genética al síndrome metabólico: una mirada comparativa entre México y el mundo. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: Genetic Susceptibility to Metabolic Syndrome: A Comparative Overview of the Mexican Population in a Global Context. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Arturo+Gallardo-Hernández%2C+Carlos%22">Arturo Gallardo-Hernández, Carlos</searchLink><relatesTo>1</relatesTo><i> argallardo@uv.mx</i><br /><searchLink fieldCode="AR" term="%22Díaz-Alberto%2C+Jaqueline%22">Díaz-Alberto, Jaqueline</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Antonio+Palma-Jacinto%2C+José%22">Antonio Palma-Jacinto, José</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Montero-Ruíz%2C+Oreth%22">Montero-Ruíz, Oreth</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Ramírez-Franco%2C+Ulises%22">Ramírez-Franco, Ulises</searchLink><relatesTo>4</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Revista+Medica+del+IMSS%22">Revista Medica del IMSS</searchLink>. jul/ago2026, Vol. 64 Issue 4, p1-10. 10p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Metabolic+syndrome%22">Metabolic syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Population+genetics%22">Population genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Regulation+of+blood+pressure%22">Regulation of blood pressure</searchLink><br /><searchLink fieldCode="DE" term="%22Glucose+metabolism%22">Glucose metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+risk+score%22">Genetic risk score</searchLink><br /><searchLink fieldCode="DE" term="%22Mexicans%22">Mexicans</searchLink><br /><searchLink fieldCode="DE" term="%22Lipid+metabolism%22">Lipid metabolism</searchLink> – Name: SubjectGeographic Label: Geographic Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Mexico%22">Mexico</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: Metabolic syndrome (MetS) is a multifactorial condition involving environmental factors, lifestyle behaviors, and genetic variants. The objective of this review was to analyze and compare the available evidence on genetic susceptibility to MetS in the Mexican population and in other regions of the world, in order to identify convergences and population-specific features. A narrative review of the scientific literature published between 2020 and 2025 was conducted using international databases. The methodological quality and scientific relevance of the studies were assessed using criteria adapted from the Q-Genie instrument. The results show that genetic variants involved in glucose and lipid metabolism, as well as in blood pressure regulation, are associated with MetS across diverse populations. However, relevant differences were identified in the frequency and phenotypic effects of these variants between the Mexican population and other regions worldwide. In conclusion, the evidence suggests that genetic susceptibility to MetS exhibits a population-specific component in Mexico. In this context, further investigation of genetic variants associated with MetS is warranted to contribute to the strengthening of preventive strategies aimed at reducing the burden of MetS in the Mexican population. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: El síndrome metabólico (SM) es una condición multifactorial en la que participan factores ambientales, estilos de vida y variantes genéticas. El objetivo de esta revisión fue analizar y comparar la evidencia disponible sobre la susceptibilidad genética al SM en la población mexicana y en otras regiones del mundo, con el fin de identificar convergencias y particularidades poblacionales. Se realizó una revisión narrativa de la literatura científica publicada entre 2020 y 2025 en bases de datos internacionales. La calidad metodológica y la pertinencia científica de los estudios se evaluaron por medio de criterios adaptados del instrumento Q-Genie. Los resultados muestran que variantes genéticas involucradas en el metabolismo de la glucosa, los lípidos y la regulación de la presión arterial se asocian con el SM en diversas poblaciones. Sin embargo, se identificaron diferencias relevantes en la frecuencia y el efecto fenotípico de estas variantes entre la población mexicana y otras regiones del mundo. En conclusión, la evidencia sugiere que la susceptibilidad genética al SM presenta un componente poblacional específico en México. En este sentido, resulta necesario profundizar en el estudio de las variantes genéticas asociadas al SM para coadyuvar en el fortalecimiento de estrategias preventivas orientadas a reducir la carga del SM en la población mexicana. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Revista Medica del IMSS is the property of Direccion de Prestaciones Medicas - IMSS and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.5281/zenodo.19076283 Languages: – Code: spa Text: Spanish PhysicalDescription: Pagination: PageCount: 10 StartPage: 1 Subjects: – SubjectFull: Metabolic syndrome Type: general – SubjectFull: Population genetics Type: general – SubjectFull: Comparative studies Type: general – SubjectFull: Regulation of blood pressure Type: general – SubjectFull: Glucose metabolism Type: general – SubjectFull: Genetic risk score Type: general – SubjectFull: Mexicans Type: general – SubjectFull: Lipid metabolism Type: general – SubjectFull: Mexico Type: general Titles: – TitleFull: Susceptibilidad genética al síndrome metabólico: una mirada comparativa entre México y el mundo. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Arturo Gallardo-Hernández, Carlos – PersonEntity: Name: NameFull: Díaz-Alberto, Jaqueline – PersonEntity: Name: NameFull: Antonio Palma-Jacinto, José – PersonEntity: Name: NameFull: Montero-Ruíz, Oreth – PersonEntity: Name: NameFull: Ramírez-Franco, Ulises IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: jul/ago2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 04435117 Numbering: – Type: volume Value: 64 – Type: issue Value: 4 Titles: – TitleFull: Revista Medica del IMSS Type: main |
| ResultId | 1 |
