DESARROLLO DE VACUNAS ANTI COVID 19: ¿SE CRUZÓ EL RUBICÓN? (Editorial).
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| Title: | DESARROLLO DE VACUNAS ANTI COVID 19: ¿SE CRUZÓ EL RUBICÓN? (Editorial). |
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| Authors: | TEGLIA, OSVALDO F.1 ofteglia@gmail.com |
| Source: | Revista Médica de Rosario. May-Aug2026, Vol. 92 Issue 2, p72-76. 5p. |
| Subjects: | COVID-19 vaccines, Vaccine development, Messenger RNA, Vaccination, Pandemics, SARS-CoV-2, Public health, Viral vaccines |
| Abstract (English): | The article examines the accelerated development of COVID-19 vaccines, using the historical metaphor of crossing the Rubicon to describe whether medical science crossed a point of no return during the pandemic. The COVID-19 outbreak, identified in December 2019 in Wuhan, was characterized by its high transmissibility, varied clinical manifestations, and unprecedented global expansion, which drove an unprecedented scientific response in the history of medicine. Unlike previous pandemics such as SARS and MERS, COVID-19 was transmitted before patients presented symptoms, even from asymptomatic individuals, which accelerated its worldwide spread. Vaccine development was accomplished in months rather than the typical fifteen years or more, thanks to accelerated authorizations from regulatory agencies, uninterrupted clinical trials that integrated multiple phases, massive government investments, advance purchase commitments, and the use of existing technological platforms such as mRNA and viral vectors. However, the article points out important criticisms regarding the inequitable distribution of vaccines between rich and poor countries, which allowed the virus to continue evolving in regions with low immunization rates, generating variants such as Omicron that escaped vaccine protection, in addition to unexpected adverse effects that generated rejection among part of the population. [Extracted from the article] |
| Abstract (Spanish): | El artículo examina el desarrollo acelerado de las vacunas contra la COVID-19, utilizando la metáfora histórica de cruzar el Rubicón para describir si la ciencia médica traspasó un punto de no retorno durante la pandemia. El brote de COVID-19, identificado en diciembre de 2019 en Wuhan, se caracterizó por su alta transmisibilidad, manifestaciones clínicas variadas y expansión global sin precedentes, lo que impulsó una respuesta científica sin paralelos en la historia de la medicina. A diferencia de pandemias anteriores como el SARS y el MERS, el COVID-19 se transmitía antes de que los pacientes presentaran síntomas, incluso desde individuos asintomáticos, lo que aceleró su propagación mundial. El desarrollo de vacunas se realizó en meses en lugar de los típicos quince años o más, gracias a autorizaciones aceleradas de agencias regulatorias, ensayos clínicos sin interrupciones que integraban múltiples fases, inversiones gubernamentales masivas, compromisos de compras anticipadas y el uso de plataformas tecnológicas ya existentes como ARNm y vectores virales. Sin embargo, el artículo señala críticas importantes respecto a la distribución inequitativa de las vacunas entre países ricos y pobres, lo que permitió que el virus continuara evolucionando en regiones con bajas tasas de inmunización, generando variantes como Ómicron que escapaban a la protección vacunal, además de efectos adversos inesperados que generaron rechazo en parte de la población. [Extracted from the article] |
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| Database: | MedicLatina |
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