Síndrome de hipersensibilidad por uso de Trimetoprim/sulfametoxazol. Reporte de un caso.

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Bibliographic Details
Title:	Síndrome de hipersensibilidad por uso de Trimetoprim/sulfametoxazol. Reporte de un caso.
Alternate Title:	Trimethoprim/sulfamethoxazole hypersensibility syndrome. A Case Report.
Authors:	Ticse Aguirre, Ray¹ rayticse@yahoo.com, Huayanay Falconi, Leandro², Malaga Rodriguez, Germán², Ferrufino Llach, Juan Carlos³, Ramos Aguilar, Cesar⁴
Source:	Revista Medica Herediana. abr-jun2006, Vol. 17 Issue 2, p109-114. 6p.
Subjects:	LEUCOCYTOSIS, LEUKOCYTE disorders, EDEMA, SULFONAMIDES, AMIDES
Abstract (English):	27 year old male, admitted to the emergency room with a 3 week history of pruriginous skin rash that began on trunk and then appeared on arms and legs. A week latter patient developed dyspnea and non productive cough. One weak prior to admission patient had desquamative skin lesions, dyspnea at rest and edema on both legs. He had a past medical history of Non-Hodgkin's B cell lymphoma and Pneumocystis jiroveci, pneumonitis treated with Trimethoprim/sulfamethoxazole 2 month prior to admission. Laboratory test showed leukocytosis with eosinophilia, cholestatic liver injury and hypoxemia. On chest X-ray the patient had an interstitial pneumonitis. Skin biopsy was positive for drug allergy. Skin lesions, hematological and systemic compromise defined the diagnosis of Trimethoprim/sulfamethoxazole hypersensibility syndrome. Drug was discontinued and corticosteroid treatment started. Case is discussed and literature was reviewed. [ABSTRACT FROM AUTHOR]
Abstract (Spanish):	Paciente varón de 27 años que fue admitido por el servicio de emergencia del Hospital Nacional Cayetano Heredia con un tiempo de enfermedad de tres semanas, que inició con rash dérmico pruriginoso en tronco, luego en extremidades. Luego de una semana presentó disnea y tos no productiva. Una semana antes del ingreso presentó descamación de piel, disnea al reposo, y edema en miembros inferiores. Como antecedente dos meses antes se le diagnosticó Linfoma no Hodgkin Células B y neumonitis por Pneumocystis jiroveci por lo que recibió trimetoprim/sulfametoxazol. Los examenes de laboratorio mostraron leucocitosis con eosinofilia, compromiso hepático con patrón colestásico e hipoxemia. La radiografía de tórax mostró neumonitis intersticial. La biopsia de piel mostró reacción alérgica a medicamentos. La erupción cutánea, el compromiso hematológico y sistémico definieron el diagnóstico de síndrome de hipersensiblidad a trimetoprim/sulfametoxazol. Se suspendió éste fármaco e inició tratamiento con corticoides. Se discute el caso y se revisa la literatura. [ABSTRACT FROM AUTHOR]
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Database:	MedicLatina

Description
Abstract:	27 year old male, admitted to the emergency room with a 3 week history of pruriginous skin rash that began on trunk and then appeared on arms and legs. A week latter patient developed dyspnea and non productive cough. One weak prior to admission patient had desquamative skin lesions, dyspnea at rest and edema on both legs. He had a past medical history of Non-Hodgkin's B cell lymphoma and Pneumocystis jiroveci, pneumonitis treated with Trimethoprim/sulfamethoxazole 2 month prior to admission. Laboratory test showed leukocytosis with eosinophilia, cholestatic liver injury and hypoxemia. On chest X-ray the patient had an interstitial pneumonitis. Skin biopsy was positive for drug allergy. Skin lesions, hematological and systemic compromise defined the diagnosis of Trimethoprim/sulfamethoxazole hypersensibility syndrome. Drug was discontinued and corticosteroid treatment started. Case is discussed and literature was reviewed. [ABSTRACT FROM AUTHOR]
ISSN:	1018130X