Bibliographic Details
| Title: |
CONCENTRACIONES PLASMATICAS DE ADIPONECTINA EN INDIVIDUOS NORMALES Y OBESOS CORRELACIONADAS CON EL PERFIL DE LIPIDOS PLASMATICOS. |
| Alternate Title: |
PLASMA ADIPONECTIN CONCENTRATIONS IN NORMAL WEIGHT AND OBESE INDIVIDUALS IS ASSOCIATED WITH PROFILE OF PLASMA LIPIDS. |
| Authors: |
Escalona O., Manuel1, Acosta B., Ana María1 |
| Source: |
Revista Chilena de Tecnología Médica. 2005, Vol. 25 Issue 1, p1171-1177. 7p. |
| Subjects: |
ADIPOSE tissues, INSULIN, DIABETES, CARDIOVASCULAR diseases, HIGH density lipoproteins, BLOOD lipids |
| Abstract (English): |
Adiponectin is an adipose tissue protein that enhances insulin sensitivity and has antiatherogenic properties. Circulating adiponectin levels are lower in men than in women and lower in obesity, type 2 diabetes and cardiovascular disease. The present study investigated the relationship between adiponectin levels with plasma lipids and the insulin resistance, in 180 normal-weight and obese individuals. We measured plasma adiponectin by RIA, serum total cholesterol, high density lipoprotein cholesterol (C-HDL), triglycerides, fasting glucose and plasma insulin. Plasma adiponectin concentrations in women higher than the men (8,45 ± 3,82 versus 6,10 ± 2,62) and insulin resistance determined by homeostasis model assessment (HOMAIR) were negatively associated with adiponectin in obese and nonobese subjects, independently of body mass index (BMI). Also, plasma adiponectin concentrations were positively correlated with C-HDL (p = 0,01) and negatively correlated with triglyceride (p = 0,05). These results indicate that high concentrations of triglycerides and low concentrations of C-HDL are associated with low plasma adiponectin concentrations. Further studies must now be targeted to determine whether adiponectin causes these lipid abnormalities. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): |
La adiponectina es una proteína del tejido adiposo que mejora la sensibilidad a la insulina y posee propiedades antiaterogénicas. Los niveles circulantes son más bajos en hombres que en mujeres y se encuentran disminuidos en la obesidad, diabetes tipo 2 y enfermedad cardiovascular. Este estudio investiga la relación entre los niveles de adiponectina con los lípidos plasmáticos y la resistencia a la insulina, en 180 individuos normales y obesos. Medimos adiponectina, mediante radioinmunoanálisis, colesterol total sérico, colesterol de HDL (C-HDL), triglicéridos, glicemia de ayuno e insulina plasmática. Las mujeres tenían la adiponectina más alta que los hombres (8,45 ± 3,82 versus 6,10 ± 2,62) y la resistencia a la insulina medida por HOMAIR se correlacionó negativamente con la adiponectina tanto en obesos como en no obesos, independientemente del índice de masa corporal (IMC). Asimismo, hubo una correlación positiva entre adiponectina y C-HDL (p = 0,01) y negativa con los triglicéridos (p = 0,05). Estos resultados indican que los niveles elevados de triglicéridos y los bajos niveles de C-HDL se asocian con concentraciones plasmáticas disminuidas de adiponectina. Se requieren mayores estudios para determinar si la adiponectina es la causante de estas anormalidades lipídicas. [ABSTRACT FROM AUTHOR] |
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| Database: |
MedicLatina |
