Efectos del aguacate como fuente de ácidos grasos monoinsaturados en lipidos séricos, metabolismo de la glucosa y reologia en pacientes con diabetes tipo 2.

Saved in:

Bibliographic Details
Title:	Efectos del aguacate como fuente de ácidos grasos monoinsaturados en lipidos séricos, metabolismo de la glucosa y reologia en pacientes con diabetes tipo 2.
Authors:	Carranza Madrigal, Jaime¹ jcmavocat@yahoo.com.mx, Alvizouri Muñoz, Mario², E. Herrera Abarca, Jorge³, Chávez Carbajal, Fortino¹
Source:	Medicina Interna de México. jul/ago2008, Vol. 24 Issue 4, p267-272. 6p. 4 Charts, 3 Graphs.
Subjects:	AVOCADO in human nutrition, UNSATURATED fatty acids, DIABETES, METABOLIC syndrome, LIPID metabolism, GLUCOSE
Abstract (English):	Background: Avocado as a source of monounsaturated acid fat has beneficial effects on lipid profile and endothelial function in diabetic and metabolic syndrome patients, and may reduce insulin sensitivity and risk of atherothrombotic events. Objective: To determine avocado's effect on lipids, glucose metabolism, and rheologic parameters in patients with type 2 diabetes. Patients and method: 21 patients with type 2 diabetes were assigned to two groups with 1,700 kcal/day diet during four weeks, in a randomized, open, blind for laboratory evaluators, and cross-over study. Diet in group 1 was avocado-free, with 50% of carbohydrates, 20% of proteins and 30% of fat in accordance with American Diabetes Association statements; and in group 2, with avocado and 75% of total fat was provided by Hass variety. Fasting plasma glucose, postprandial glucose, glycosilated hemoglobin, insulin sensitivity (by HOMA method), total cholesterol, triglycerides, HDL cholesterol, serum lipoperoxidation, platelet aggregation, blood viscosity, and osmotic fragility of erythrocytes were measured, and LDL cholesterol estimated at basal and after each diet. Results: Both diets resulted in reductions of fasting plasma glucose, glycosilated hemoglobin, insulin sensitivity (significantly lower in group 2), total cholesterol, triglycerides, LDL cholesterol, and blood viscosity. None of them modified HDL cholesterol values. Group 2 diet increased serum lipoperoxidation and reduced platelet aggregation 90 seconds after the stimulus, and increased osmotic fragility of erythrocytes. Conclusions: Avocado can be used in dietary treatment of type 2 diabetes with some advantages over traditional diets used for that purpose. [ABSTRACT FROM AUTHOR]
Abstract (Spanish):	Antecedentes: el aguacate, como fuente de ácidos grasos monoinsaturados, mejora el perfil de lípidos y la función endotelial en pacientes diabéticos y con síndrome metabólico, también puede reducir la sensibilidad a la insulina y el riesgo de eventos aterotrombóticos. Objetivo: determinar el efecto del aguacate en los lípidos, el metabolismo de la glucosa y los parámetros reológicos en pacientes con diabetes tipo 2. Pacientes y método: se incluyeron 21 pacientes con diabetes tipo 2 que se asignaron a dos grupos con dieta de 1,700 kcal/día durante cuatro semanas, en un estudio abierto, aleatorizado, ciego para los evaluadores del laboratorio y cruzado. En el grupo 1 la dieta fue sin aguacate y en el 2 con aguacate, con 50% de carbohidratos, 20% de proteínas y 30% de grasas, según las recomendaciones de la American Diabetes Association; en el 2, 75% de la grasa total fue aportado por la variedad Hass. Se midieron: glucosa en ayuno, glucosa de dos horas posprandial, hemoglobina glucosilada, resistencia a la insulina (método de evaluación homeostásica), colesterol total, triglicéridos, colesterol HDL, lipoperoxidación, agregación plaquetaria, viscosidad sanguínea y fragilidad osmótica de los eritrocitos; y se calculó el colesterol LDL al principio y final del periodo de cada dieta. Resultados: ambas dietas redujeron la glucosa en ayuno, la hemoglobina glucosilada, la resistencia a la insulina (significativamente menor en el grupo 2), el colesterol total, los triglicéridos, el colesterol LDL y la viscosidad sanguínea; ninguna modificó las concentraciones de colesterol HDL. La del grupo 2 aumentó la lipoperoxidación y disminuyó la agregación plaquetaria a los 90 segundos del estímulo proagregante, y aumentó significativamente la fragilidad osmótica de los eritrocitos. Conclusiones: el aguacate puede prescribirse para el tratamiento dietético de la diabetes y tiene algunas ventajas sobre las dietas que ya se indican para tal fin. [ABSTRACT FROM AUTHOR]
	Copyright of Medicina Interna de México is the property of Colegio de Medicina Interna de Mexico and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database:	MedicLatina

Description
Abstract:	Background: Avocado as a source of monounsaturated acid fat has beneficial effects on lipid profile and endothelial function in diabetic and metabolic syndrome patients, and may reduce insulin sensitivity and risk of atherothrombotic events. Objective: To determine avocado's effect on lipids, glucose metabolism, and rheologic parameters in patients with type 2 diabetes. Patients and method: 21 patients with type 2 diabetes were assigned to two groups with 1,700 kcal/day diet during four weeks, in a randomized, open, blind for laboratory evaluators, and cross-over study. Diet in group 1 was avocado-free, with 50% of carbohydrates, 20% of proteins and 30% of fat in accordance with American Diabetes Association statements; and in group 2, with avocado and 75% of total fat was provided by Hass variety. Fasting plasma glucose, postprandial glucose, glycosilated hemoglobin, insulin sensitivity (by HOMA method), total cholesterol, triglycerides, HDL cholesterol, serum lipoperoxidation, platelet aggregation, blood viscosity, and osmotic fragility of erythrocytes were measured, and LDL cholesterol estimated at basal and after each diet. Results: Both diets resulted in reductions of fasting plasma glucose, glycosilated hemoglobin, insulin sensitivity (significantly lower in group 2), total cholesterol, triglycerides, LDL cholesterol, and blood viscosity. None of them modified HDL cholesterol values. Group 2 diet increased serum lipoperoxidation and reduced platelet aggregation 90 seconds after the stimulus, and increased osmotic fragility of erythrocytes. Conclusions: Avocado can be used in dietary treatment of type 2 diabetes with some advantages over traditional diets used for that purpose. [ABSTRACT FROM AUTHOR]
ISSN:	01864866