Sistemas de adquisición de hierro en Salmonella enterica.

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Bibliographic Details
Title:	Sistemas de adquisición de hierro en Salmonella enterica.
Alternate Title:	Iron Acquisition Systems in Salmonella enterica.
Authors:	Elisa Drago-Serrano, María¹ dragome@yahoo.com
Source:	Revista Biomedica. ene-abr2009, Vol. 20 Issue 1, p41-54. 14p. 1 Chart.
Subjects:	SALMONELLA, IRON ions, CATIONS, PROTEINS, TRANSFERRIN
Abstract (English):	Objective.The components for the iron-acquisition systems currently described in Salmonella enterica in some cases are involved in growth, survival and bacterial virulence. Results. Iron as ferric ion (Fe3+) or ferrous (Fe2+) has an essential role as a cofactor for enzymes involved in oxidation-reduction reactions, which are crucial for enteropathogenic bacteria such as Salmonella enterica. In biological fluids, free iron is toxic in its ionic form; therefore, it is sequestered by transferrins that reduce the availability for nutritional requirements of Salmonella enterica. Under iron-limiting conditions, Salmonella enterica produces endogenous siderophores or uses exogenous siderophores to uptake Fe3+. After being formed, the ferrisiderophore complexes bind to the receptor proteins on the bacterial outer membrane to be then transported to the periplasmic space by the transperiplasmic complex Ton and then to the cytoplasm by ABC type inner membrane permeases. Salmonella enterica has other inner membrane permeases to capture divalent metal cations in a siderophore independent pathway, these include the ABC type transporter Feo to acquire Fe2+ and the ABC type and Nramp1 like permeases SitABCD and MntH which act primarily as transporters of manganese cations (Mn2+) but transport Fe2+ as a secondary effect. Conclusion. A better understanding of iron uptake systems in Salmonella enterica could help for the development of antibiotics, vaccines and methods of isolation intended for therapeutic purposes, prophylactics and diagnostics. [ABSTRACT FROM AUTHOR]
Abstract (Spanish):	Objetivo. Exponer los sistemas de adquisición de hierro descritos actualmente en Salmonella enterica cuyos componentes, en ciertos casos, están implicados en el crecimiento, sobrevivencia y virulencia bacteriana. Resultados. El hierro en forma de ión férrico (Fe3+) o ferroso (Fe2+) tiene un papel esencial como cofactor de enzimas involucradas en reacciones de óxido-reducción, vitales para bacterias enteropatógenas como Salmonella enterica. En fluidos biológicos, el hierro libre en forma iónica es tóxico; por ello, es secuestrado por transferrinas que disminuyen su disponibilidad para los requerimientos nutricionales de Salmonella enterica. Bajo condiciones restrictivas de hierro, Salmonella enterica secreta sideróforos endógenos o utiliza sideróforos exógenos para captar e incorporar Fe3+. Al formarse, los complejos ferrisideróforos se unen a receptores proteicos de la membrana bacteriana externa, para ser transportados al espacio periplásmico por el complejo transperiplásmico Ton, y después al citoplasma, por permeasas ABC de membrana citoplásmica. Salmonella enterica cuenta con otras permeasas de membrana interna para obtener cationes metálicos divalentes en una ruta sideróforo independiente; estas permeasas incluyen al transportador tipo ABC Feo para importar Fe2+ y a las permeasas de tipo ABC y Nramp1, SitABCD y MntH respectivamente, que actúan primariamente como transportadores de cationes manganeso (Mn2+) y en forma secundaria transportan Fe2+. Conclusión. Un mejor entendimiento de los sistemas de adquisición de hierro en Salmonella enterica podría sentar las bases para el desarrollo de antibióticos, vacunas y métodos de aislamiento, destinados para propósitos terapéuticos, profilácticos y diagnósticos. [ABSTRACT FROM AUTHOR]
	Copyright of Revista Biomedica is the property of Centro de Investigaciones Regionales Dr. Hideyo Noguchi; Facultad de Medicina, UADY and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database:	MedicLatina

Description
Abstract:	Objective.The components for the iron-acquisition systems currently described in Salmonella enterica in some cases are involved in growth, survival and bacterial virulence. Results. Iron as ferric ion (Fe3+) or ferrous (Fe2+) has an essential role as a cofactor for enzymes involved in oxidation-reduction reactions, which are crucial for enteropathogenic bacteria such as Salmonella enterica. In biological fluids, free iron is toxic in its ionic form; therefore, it is sequestered by transferrins that reduce the availability for nutritional requirements of Salmonella enterica. Under iron-limiting conditions, Salmonella enterica produces endogenous siderophores or uses exogenous siderophores to uptake Fe3+. After being formed, the ferrisiderophore complexes bind to the receptor proteins on the bacterial outer membrane to be then transported to the periplasmic space by the transperiplasmic complex Ton and then to the cytoplasm by ABC type inner membrane permeases. Salmonella enterica has other inner membrane permeases to capture divalent metal cations in a siderophore independent pathway, these include the ABC type transporter Feo to acquire Fe2+ and the ABC type and Nramp1 like permeases SitABCD and MntH which act primarily as transporters of manganese cations (Mn2+) but transport Fe2+ as a secondary effect. Conclusion. A better understanding of iron uptake systems in Salmonella enterica could help for the development of antibiotics, vaccines and methods of isolation intended for therapeutic purposes, prophylactics and diagnostics. [ABSTRACT FROM AUTHOR]
ISSN:	0188493X