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Comparación de los efectos sedantes de dexmedetomidina con y sin dosis de impregnación en pacientes bajo anestesia regional.

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Title: Comparación de los efectos sedantes de dexmedetomidina con y sin dosis de impregnación en pacientes bajo anestesia regional.
Authors: Landeros-Navarro, Isette Yunue1 yunita20@yahoo.com.mx, Zepeda-López, Vilma
Source: Revista Mexicana de Anestesiología. jul-sep2009, Vol. 32 Issue 3, p150-155. 6p. 1 Chart, 3 Graphs.
Subjects: SEDATIVES, CATECHOLAMINES, ANALGESICS, SURGERY, PHYSIOLOGICAL effects of oxygen
Abstract (English): Introduction: Dexmedetomidine has sedative, hypnotic, analgesic, and sympatholytic properties. It also decreases the release of catecholamines and diminishes opiate requirement and inhaled analgesics. The patient's well-being during the surgical intervention includes a proper sedation. Our objective in this study consists of comparing the differences in dexmedetomidine sedation effects with and without impregnation in patients under regional anesthesia. Methodology: The study used 2 groups of 30 patients each under regional anesthesia. Group A: Impregnation of 0.5 µg/kg for 20 minutes before the surgery and maintenance of 0.3 µg/kg/hour. Group B: Infusion of 0.3 µg/kg/hour. The following parameters were evaluated: sedation level (Ramsay) mean arterial pressure, cardiac frequency, arterial oxygen saturation every 5 minutes during the transoperative period. Results: Anxiolysis is similar when using dexmedetomidine with and without impregnation (p 0.712). The observed side effects were hypotension and bradycardia. There was no significant difference between both groups with regard to mean arterial pressure (p 0.256), cardiac tenfrequency (p 0.407), arterial oxygen saturation (p 0.581). These findings were similar to other researches. Conclusion: Dexmedetomidine given with and without impregnation produces similar sedation. The incidence of side effects with both administration techniques is similar. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Introducción: La dexmedetomidina posee propiedades sedantes, hipnóticas, analgésicas, simpaticolíticas y disminución de la liberación de catecolaminas, disminuyendo los requerimientos de opioides, anestésicos inhalados. El bienestar del paciente durante la intervención quirúrgica incluye una apropiada sedación. Objetivo: Comparar las diferencias de los efectos sedantes de la dexmedetomidina con y sin impregnación en pacientes bajo anestesia regional. Metodología: Formación de 2 grupos de 30 pacientes bajo anestesia regional. Grupo A: Impregnación de 0.5 µg/kg durante 20 minutos pre-cirugía y mantenimiento de 0.3 µg/kg/hora. Grupo B: Infusión de 0.3 µg/kg/hora. Se evaluó el nivel de sedación (Ramsay) tensión arterial media, frecuencia cardíaca, saturación arterial de oxígeno cada 5 minutos durante el transoperatorio. Resultados: La ansiólisis es similar al utilizar dexmedetomidina con y sin dosis de impregnación (p 0.712). Los efectos colaterales observados fueron hipotensión y bradicardia. Entre grupos no existió diferencia significativa en tensión arterial media (p 0.256), frecuencia cardíaca (p 0.407) saturación arterial de oxígeno (p 0.581), resultados similares en otras investigaciones. Conclusión: La dexmedetomidina administrada con y sin impregnación produce sedación similar. La incidencia de efectos secundarios con ambas técnicas de administración es similar. [ABSTRACT FROM AUTHOR]
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Database: MedicLatina
Description
Abstract:Introduction: Dexmedetomidine has sedative, hypnotic, analgesic, and sympatholytic properties. It also decreases the release of catecholamines and diminishes opiate requirement and inhaled analgesics. The patient's well-being during the surgical intervention includes a proper sedation. Our objective in this study consists of comparing the differences in dexmedetomidine sedation effects with and without impregnation in patients under regional anesthesia. Methodology: The study used 2 groups of 30 patients each under regional anesthesia. Group A: Impregnation of 0.5 µg/kg for 20 minutes before the surgery and maintenance of 0.3 µg/kg/hour. Group B: Infusion of 0.3 µg/kg/hour. The following parameters were evaluated: sedation level (Ramsay) mean arterial pressure, cardiac frequency, arterial oxygen saturation every 5 minutes during the transoperative period. Results: Anxiolysis is similar when using dexmedetomidine with and without impregnation (p 0.712). The observed side effects were hypotension and bradycardia. There was no significant difference between both groups with regard to mean arterial pressure (p 0.256), cardiac tenfrequency (p 0.407), arterial oxygen saturation (p 0.581). These findings were similar to other researches. Conclusion: Dexmedetomidine given with and without impregnation produces similar sedation. The incidence of side effects with both administration techniques is similar. [ABSTRACT FROM AUTHOR]
ISSN:04847903