SEROTONINA: UN MENSAJERO ENTRE EL CEREBRO, EL INTESTINO Y EL HUESO.

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Bibliographic Details
Title:	SEROTONINA: UN MENSAJERO ENTRE EL CEREBRO, EL INTESTINO Y EL HUESO.
Alternate Title:	SEROTONIN: A MESSENGER BETWEEN THE BRAIN, THE GUT, AND BONE.
Authors:	Sánchez, Ariel¹ asanchez@cimero.org.ar
Source:	Actualizaciones en Osteología. 2012, Vol. 8 Issue 2, p79-85. 7p. 1 Diagram.
Subjects:	SEROTONIN antagonists, SEROTONIN, OSTEOPENIA, AFFECTIVE disorders, MENTAL health services, RISK factors of fractures, OSTEOPOROSIS treatment
Abstract (English):	In the last few years there has been an accumulation of knowledge about the role of serotonin on bone turnovei There seems to be a dual effect, with brain serotonin having an anabolic influence on bone, and gut serotonin inhibiting osteoblastic function, although there is a recent controversy about this. Selective serotonin reuptake inhibitors, widely used to treat mood disorders, induce osteopenia and increase fracture risk Approaches are being studied to modulate the production of gut serotonin as a possible treatment against osteoporosis. However, there is a long road ahead before translating basic findings to clinical practice. [ABSTRACT FROM AUTHOR]
Abstract (Spanish):	En los ültimos años ha crecido el conocimiento sobre el papel de la serotonina en el recambio óseo. Parece haber un efecto dual, con la serotonina cerebral ejerciendo un efecto anabólico sobre el hueso y la serotonina intestinal frenando la función osteoblástica, pero han surgido controversias recientes al respecto. Los inhibidores selectivos de la recaptación de serotonina, ampliamente usados para tratar desárdenes afectivos, inducen osteopenia y aumentan el riesgo de fracturas. Se abre a posibilidad de intervenir farmacolópara modular la producción de serotonina intestinal como eventual tratamiento de la osteoporosis, pero falta todavía recorrer un largo camino para trasladar los hallazgos básicos a la clinica. [ABSTRACT FROM AUTHOR]
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Database:	MedicLatina

Description
Abstract:	In the last few years there has been an accumulation of knowledge about the role of serotonin on bone turnovei There seems to be a dual effect, with brain serotonin having an anabolic influence on bone, and gut serotonin inhibiting osteoblastic function, although there is a recent controversy about this. Selective serotonin reuptake inhibitors, widely used to treat mood disorders, induce osteopenia and increase fracture risk Approaches are being studied to modulate the production of gut serotonin as a possible treatment against osteoporosis. However, there is a long road ahead before translating basic findings to clinical practice. [ABSTRACT FROM AUTHOR]
ISSN:	16698975