Disfunción mitocondrial como explicación del síndrome de disfunción orgánica múltiple en la sepsis.

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Bibliographic Details
Title:	Disfunción mitocondrial como explicación del síndrome de disfunción orgánica múltiple en la sepsis.
Authors:	Duarte-Mote, Jesús¹ hgnsjduarte@yahoo.com.mx, Domínguez H., Irene², Vega H., Cristina³, Lee Eng C., Víctor⁴, Romero F., Socorro⁵, Espinosa L., Rogelio⁶, Sánchez R., Graciela⁷
Source:	Medicina Interna de México. sep/oct2013, Vol. 29 Issue 5, p504-512. 9p.
Subjects:	MITOCHONDRIAL pathology, INTENSIVE care units, MORTALITY, INFLAMMATION, SEPSIS, MULTIPLE organ failure, CALORIC expenditure, SCIENTIFIC observation
Abstract (English):	Sepsis is still the leading cause of death in intensive care units. New therapeutic approach based on goals achieved to reduce the mortality rate, however continues to be high. During the evolution of the septic process, the systemic inflammatory response and metabolic response to trauma form the two main responses of compensatory type with which the organism is faced with sepsis. The different phases of the metabolic response to trauma denote different stages of organic adaptation, which often first evolves to a phase of multiple organ dysfunction and then a multiple organic failure. Basal energy expenditure in patients with sepsis is greatly diminished at the stage corresponding to multiple organ dysfunction. At this stage, the functional alterations that are observed are secondary to disoxia and decrease in the production of energy at the mitochondrial level. This phase of dysfunction is thought to be an adaptive phase of the body with the purpose of preserving the organic cell structure. In this article, we reviewed the mitochondrial alterations that are observed during the phase of multiple organ dysfunctions, its relationship with the therapeutic approach and the importance in mortality of these patients. [ABSTRACT FROM AUTHOR]
Abstract (Spanish):	La sepsis sigue siendo la principal causa de muerte en las unidades de cuidados intensivos. El nuevo abordaje terapéutico basado en metas ha logrado disminuir el índice de mortalidad; sin embargo, continúa siendo alto. Durante la evolución del proceso séptico, las respuestas inflamatoria sistémica y metabólica al traumatismo conforman las dos principales respuestas de tipo compensatorio con los que el organismo hace frente a la sepsis. Las diferentes fases de la respuesta metabólica al traumatismo denotan diferentes etapas de adaptación orgánica, que muchas veces evolucionan primero a una fase de disfunción orgánica múltiple y luego a una franca insuficiencia orgánica múltiple. El gasto energético basal de los pacientes con sepsis disminuye de manera importante en la etapa de disfunción orgánica múltiple. Las alteraciones funcionales son secundarias a disoxia y menor producción energética en la mitocondria. Esta fase de disfunción puede ser adaptativa del organismo para preservar la citoestructura orgánica. En este artículo se revisan las alteraciones mitocondriales durante la fase de disfunción orgánica múltiple, su relación con el abordaje terapéutico y la importancia en la mortalidad. [ABSTRACT FROM AUTHOR]
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Database:	MedicLatina

Description
Abstract:	Sepsis is still the leading cause of death in intensive care units. New therapeutic approach based on goals achieved to reduce the mortality rate, however continues to be high. During the evolution of the septic process, the systemic inflammatory response and metabolic response to trauma form the two main responses of compensatory type with which the organism is faced with sepsis. The different phases of the metabolic response to trauma denote different stages of organic adaptation, which often first evolves to a phase of multiple organ dysfunction and then a multiple organic failure. Basal energy expenditure in patients with sepsis is greatly diminished at the stage corresponding to multiple organ dysfunction. At this stage, the functional alterations that are observed are secondary to disoxia and decrease in the production of energy at the mitochondrial level. This phase of dysfunction is thought to be an adaptive phase of the body with the purpose of preserving the organic cell structure. In this article, we reviewed the mitochondrial alterations that are observed during the phase of multiple organ dysfunctions, its relationship with the therapeutic approach and the importance in mortality of these patients. [ABSTRACT FROM AUTHOR]
ISSN:	01864866