Discovery of sodium R-(+)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate (elagolix), a potent and orally available nonpeptide antagonist of the human gonadotropin-releasing hormone receptor.
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| Title: | Discovery of sodium R-(+)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate (elagolix), a potent and orally available nonpeptide antagonist of the human gonadotropin-releasing hormone receptor. |
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| Authors: | Chen C; Department of Medicinal Chemistry, Neurocrine Biosciences, Inc., 12790 El Camino Real, San Diego, California 92130, USA. cchen@neurocrine.com, Wu D, Guo Z, Xie Q, Reinhart GJ, Madan A, Wen J, Chen T, Huang CQ, Chen M, Chen Y, Tucci FC, Rowbottom M, Pontillo J, Zhu YF, Wade W, Saunders J, Bozigian H, Struthers RS |
| Source: | Journal of medicinal chemistry [J Med Chem] 2008 Dec 11; Vol. 51 (23), pp. 7478-85. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 19006286 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Discovery of sodium R-(+)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate (elagolix), a potent and orally available nonpeptide antagonist of the human gonadotropin-releasing hormone receptor. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Chen+C%22">Chen C</searchLink>; Department of Medicinal Chemistry, Neurocrine Biosciences, Inc., 12790 El Camino Real, San Diego, California 92130, USA. cchen@neurocrine.com<br /><searchLink fieldCode="AU" term="%22Wu+D%22">Wu D</searchLink><br /><searchLink fieldCode="AU" term="%22Guo+Z%22">Guo Z</searchLink><br /><searchLink fieldCode="AU" term="%22Xie+Q%22">Xie Q</searchLink><br /><searchLink fieldCode="AU" term="%22Reinhart+GJ%22">Reinhart GJ</searchLink><br /><searchLink fieldCode="AU" term="%22Madan+A%22">Madan A</searchLink><br /><searchLink fieldCode="AU" term="%22Wen+J%22">Wen J</searchLink><br /><searchLink fieldCode="AU" term="%22Chen+T%22">Chen T</searchLink><br /><searchLink fieldCode="AU" term="%22Huang+CQ%22">Huang CQ</searchLink><br /><searchLink fieldCode="AU" term="%22Chen+M%22">Chen M</searchLink><br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink><br /><searchLink fieldCode="AU" term="%22Tucci+FC%22">Tucci FC</searchLink><br /><searchLink fieldCode="AU" term="%22Rowbottom+M%22">Rowbottom M</searchLink><br /><searchLink fieldCode="AU" term="%22Pontillo+J%22">Pontillo J</searchLink><br /><searchLink fieldCode="AU" term="%22Zhu+YF%22">Zhu YF</searchLink><br /><searchLink fieldCode="AU" term="%22Wade+W%22">Wade W</searchLink><br /><searchLink fieldCode="AU" term="%22Saunders+J%22">Saunders J</searchLink><br /><searchLink fieldCode="AU" term="%22Bozigian+H%22">Bozigian H</searchLink><br /><searchLink fieldCode="AU" term="%22Struthers+RS%22">Struthers RS</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2008 Dec 11; Vol. 51 (23), pp. 7478-85. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=19006286 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1021/jm8006454 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 7478 Titles: – TitleFull: Discovery of sodium R-(+)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate (elagolix), a potent and orally available nonpeptide antagonist of the human gonadotropin-releasing hormone receptor. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Chen C – PersonEntity: Name: NameFull: Wu D – PersonEntity: Name: NameFull: Guo Z – PersonEntity: Name: NameFull: Xie Q – PersonEntity: Name: NameFull: Reinhart GJ – PersonEntity: Name: NameFull: Madan A – PersonEntity: Name: NameFull: Wen J – PersonEntity: Name: NameFull: Chen T – PersonEntity: Name: NameFull: Huang CQ – PersonEntity: Name: NameFull: Chen M – PersonEntity: Name: NameFull: Chen Y – PersonEntity: Name: NameFull: Tucci FC – PersonEntity: Name: NameFull: Rowbottom M – PersonEntity: Name: NameFull: Pontillo J – PersonEntity: Name: NameFull: Zhu YF – PersonEntity: Name: NameFull: Wade W – PersonEntity: Name: NameFull: Saunders J – PersonEntity: Name: NameFull: Bozigian H – PersonEntity: Name: NameFull: Struthers RS IsPartOfRelationships: – BibEntity: Dates: – D: 11 M: 12 Text: 2008 Dec 11 Type: published Y: 2008 Identifiers: – Type: issn-electronic Value: 1520-4804 Numbering: – Type: volume Value: 51 – Type: issue Value: 23 Titles: – TitleFull: Journal of medicinal chemistry Type: main |
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