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Analysis of imatinib and sorafenib binding to p38alpha compared with c-Abl and b-Raf provides structural insights for understanding the selectivity of inhibitors targeting the DFG-out form of protein kinases.

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Title: Analysis of imatinib and sorafenib binding to p38alpha compared with c-Abl and b-Raf provides structural insights for understanding the selectivity of inhibitors targeting the DFG-out form of protein kinases.
Authors: Namboodiri HV; Department of Biology, Locus Pharmaceuticals, Inc, Four Valley Square, 512 East Township Line Rd,Blue Bell, Pennsylvania 19422, USA. vnamboodiri@ansarisbio.com, Bukhtiyarova M, Ramcharan J, Karpusas M, Lee Y, Springman EB
Source: Biochemistry [Biochemistry] 2010 May 04; Vol. 49 (17), pp. 3611-8.
Publication Type: Comparative Study; Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Analysis of imatinib and sorafenib binding to p38alpha compared with c-Abl and b-Raf provides structural insights for understanding the selectivity of inhibitors targeting the DFG-out form of protein kinases.
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  Data: <searchLink fieldCode="AU" term="%22Namboodiri+HV%22">Namboodiri HV</searchLink>; Department of Biology, Locus Pharmaceuticals, Inc, Four Valley Square, 512 East Township Line Rd,Blue Bell, Pennsylvania 19422, USA. vnamboodiri@ansarisbio.com<br /><searchLink fieldCode="AU" term="%22Bukhtiyarova+M%22">Bukhtiyarova M</searchLink><br /><searchLink fieldCode="AU" term="%22Ramcharan+J%22">Ramcharan J</searchLink><br /><searchLink fieldCode="AU" term="%22Karpusas+M%22">Karpusas M</searchLink><br /><searchLink fieldCode="AU" term="%22Lee+Y%22">Lee Y</searchLink><br /><searchLink fieldCode="AU" term="%22Springman+EB%22">Springman EB</searchLink>
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  Data: <searchLink fieldCode="JN" term="%220370623%22">Biochemistry</searchLink> [Biochemistry] 2010 May 04; Vol. 49 (17), pp. 3611-8.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0370623 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4995 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200062960%22">00062960 </searchLink><i>NLM ISO Abbreviation: </i>Biochemistry <i>Subsets: </i>MEDLINE
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        Value: 10.1021/bi100070r
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        Text: English
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        StartPage: 3611
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      – TitleFull: Analysis of imatinib and sorafenib binding to p38alpha compared with c-Abl and b-Raf provides structural insights for understanding the selectivity of inhibitors targeting the DFG-out form of protein kinases.
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              Text: 2010 May 04
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              Y: 2010
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