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Quantitative pharmacokinetic/pharmacodynamic analyses suggest that the 129/SVE mouse is a suitable preclinical pharmacology model for identifying small-molecule γ-secretase inhibitors.

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Title: Quantitative pharmacokinetic/pharmacodynamic analyses suggest that the 129/SVE mouse is a suitable preclinical pharmacology model for identifying small-molecule γ-secretase inhibitors.
Authors: Lu Y; Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, USA Yasong.Lu@pfizer.com, Zhang L, Nolan CE, Becker SL, Atchison K, Robshaw AE, Pustilnik LR, Osgood SM, Miller EH, Stepan AF, Subramanyam C, Efremov I, Hallgren AJ, Riddell D
Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2011 Dec; Vol. 339 (3), pp. 922-34. Date of Electronic Publication: 2011 Sep 19.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Quantitative pharmacokinetic/pharmacodynamic analyses suggest that the 129/SVE mouse is a suitable preclinical pharmacology model for identifying small-molecule γ-secretase inhibitors.
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  Data: <searchLink fieldCode="AU" term="%22Lu+Y%22">Lu Y</searchLink>; Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, USA Yasong.Lu@pfizer.com<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink><br /><searchLink fieldCode="AU" term="%22Nolan+CE%22">Nolan CE</searchLink><br /><searchLink fieldCode="AU" term="%22Becker+SL%22">Becker SL</searchLink><br /><searchLink fieldCode="AU" term="%22Atchison+K%22">Atchison K</searchLink><br /><searchLink fieldCode="AU" term="%22Robshaw+AE%22">Robshaw AE</searchLink><br /><searchLink fieldCode="AU" term="%22Pustilnik+LR%22">Pustilnik LR</searchLink><br /><searchLink fieldCode="AU" term="%22Osgood+SM%22">Osgood SM</searchLink><br /><searchLink fieldCode="AU" term="%22Miller+EH%22">Miller EH</searchLink><br /><searchLink fieldCode="AU" term="%22Stepan+AF%22">Stepan AF</searchLink><br /><searchLink fieldCode="AU" term="%22Subramanyam+C%22">Subramanyam C</searchLink><br /><searchLink fieldCode="AU" term="%22Efremov+I%22">Efremov I</searchLink><br /><searchLink fieldCode="AU" term="%22Hallgren+AJ%22">Hallgren AJ</searchLink><br /><searchLink fieldCode="AU" term="%22Riddell+D%22">Riddell D</searchLink>
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  Data: <searchLink fieldCode="JN" term="%220376362%22">The Journal of pharmacology and experimental therapeutics</searchLink> [J Pharmacol Exp Ther] 2011 Dec; Vol. 339 (3), pp. 922-34. <i>Date of Electronic Publication: </i>2011 Sep 19.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>0376362 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1521-0103 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200223565%22">00223565 </searchLink><i>NLM ISO Abbreviation: </i>J Pharmacol Exp Ther <i>Subsets: </i>MEDLINE
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        Value: 10.1124/jpet.111.186791
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      – Code: eng
        Text: English
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        StartPage: 922
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      – TitleFull: Quantitative pharmacokinetic/pharmacodynamic analyses suggest that the 129/SVE mouse is a suitable preclinical pharmacology model for identifying small-molecule γ-secretase inhibitors.
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              Text: 2011 Dec
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