A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase.

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Bibliographic Details
Title: A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase.
Authors: Morgan HP; Centre for Translational and Chemical Biology, School of Biological Sciences, University of Edinburgh, Michael Swann Building, The King's Buildings, Mayfield Road, Edinburgh EH9 3JR, UK., Walsh MJ, Blackburn EA, Wear MA, Boxer MB, Shen M, Veith H, McNae IW, Nowicki MW, Michels PA, Auld DS, Fothergill-Gilmore LA, Walkinshaw MD
Source: The Biochemical journal [Biochem J] 2012 Nov 15; Vol. 448 (1), pp. 67-72.
Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1470-8728
DOI:10.1042/BJ20121014