A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase.

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Title: A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase.
Authors: Morgan HP; Centre for Translational and Chemical Biology, School of Biological Sciences, University of Edinburgh, Michael Swann Building, The King's Buildings, Mayfield Road, Edinburgh EH9 3JR, UK., Walsh MJ, Blackburn EA, Wear MA, Boxer MB, Shen M, Veith H, McNae IW, Nowicki MW, Michels PA, Auld DS, Fothergill-Gilmore LA, Walkinshaw MD
Source: The Biochemical journal [Biochem J] 2012 Nov 15; Vol. 448 (1), pp. 67-72.
Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase.
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  Data: <searchLink fieldCode="AU" term="%22Morgan+HP%22">Morgan HP</searchLink>; Centre for Translational and Chemical Biology, School of Biological Sciences, University of Edinburgh, Michael Swann Building, The King's Buildings, Mayfield Road, Edinburgh EH9 3JR, UK.<br /><searchLink fieldCode="AU" term="%22Walsh+MJ%22">Walsh MJ</searchLink><br /><searchLink fieldCode="AU" term="%22Blackburn+EA%22">Blackburn EA</searchLink><br /><searchLink fieldCode="AU" term="%22Wear+MA%22">Wear MA</searchLink><br /><searchLink fieldCode="AU" term="%22Boxer+MB%22">Boxer MB</searchLink><br /><searchLink fieldCode="AU" term="%22Shen+M%22">Shen M</searchLink><br /><searchLink fieldCode="AU" term="%22Veith+H%22">Veith H</searchLink><br /><searchLink fieldCode="AU" term="%22McNae+IW%22">McNae IW</searchLink><br /><searchLink fieldCode="AU" term="%22Nowicki+MW%22">Nowicki MW</searchLink><br /><searchLink fieldCode="AU" term="%22Michels+PA%22">Michels PA</searchLink><br /><searchLink fieldCode="AU" term="%22Auld+DS%22">Auld DS</searchLink><br /><searchLink fieldCode="AU" term="%22Fothergill-Gilmore+LA%22">Fothergill-Gilmore LA</searchLink><br /><searchLink fieldCode="AU" term="%22Walkinshaw+MD%22">Walkinshaw MD</searchLink>
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  Data: <searchLink fieldCode="JN" term="%222984726R%22">The Biochemical journal</searchLink> [Biochem J] 2012 Nov 15; Vol. 448 (1), pp. 67-72.
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              Text: 2012 Nov 15
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