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Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: the discovery of AZD8055 and AZD2014.

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Title: Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: the discovery of AZD8055 and AZD2014.
Authors: Pike KG; AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK. kurt.pike@astrazeneca.com, Malagu K, Hummersone MG, Menear KA, Duggan HM, Gomez S, Martin NM, Ruston L, Pass SL, Pass M
Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 Mar 01; Vol. 23 (5), pp. 1212-6. Date of Electronic Publication: 2013 Jan 18.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: the discovery of AZD8055 and AZD2014.
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  Data: <searchLink fieldCode="AU" term="%22Pike+KG%22">Pike KG</searchLink>; AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK. kurt.pike@astrazeneca.com<br /><searchLink fieldCode="AU" term="%22Malagu+K%22">Malagu K</searchLink><br /><searchLink fieldCode="AU" term="%22Hummersone+MG%22">Hummersone MG</searchLink><br /><searchLink fieldCode="AU" term="%22Menear+KA%22">Menear KA</searchLink><br /><searchLink fieldCode="AU" term="%22Duggan+HM%22">Duggan HM</searchLink><br /><searchLink fieldCode="AU" term="%22Gomez+S%22">Gomez S</searchLink><br /><searchLink fieldCode="AU" term="%22Martin+NM%22">Martin NM</searchLink><br /><searchLink fieldCode="AU" term="%22Ruston+L%22">Ruston L</searchLink><br /><searchLink fieldCode="AU" term="%22Pass+SL%22">Pass SL</searchLink><br /><searchLink fieldCode="AU" term="%22Pass+M%22">Pass M</searchLink>
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  Data: <searchLink fieldCode="JN" term="%229107377%22">Bioorganic & medicinal chemistry letters</searchLink> [Bioorg Med Chem Lett] 2013 Mar 01; Vol. 23 (5), pp. 1212-6. <i>Date of Electronic Publication: </i>2013 Jan 18.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ltd%22">Elsevier Science Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9107377 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1464-3405 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220960894X%22">0960894X </searchLink><i>NLM ISO Abbreviation: </i>Bioorg Med Chem Lett <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1016/j.bmcl.2013.01.019
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      – Code: eng
        Text: English
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        StartPage: 1212
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      – TitleFull: Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: the discovery of AZD8055 and AZD2014.
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              Text: 2013 Mar 01
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              Y: 2013
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