Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases.
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| Title: | Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases. |
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| Authors: | Addie M; Oncology iMed, AstraZeneca, Alderley Park, Macclesfield SK10 4TG, United Kingdom., Ballard P, Buttar D, Crafter C, Currie G, Davies BR, Debreczeni J, Dry H, Dudley P, Greenwood R, Johnson PD, Kettle JG, Lane C, Lamont G, Leach A, Luke RW, Morris J, Ogilvie D, Page K, Pass M, Pearson S, Ruston L |
| Source: | Journal of medicinal chemistry [J Med Chem] 2013 Mar 14; Vol. 56 (5), pp. 2059-73. Date of Electronic Publication: 2013 Feb 26. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 23394218 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Addie+M%22">Addie M</searchLink>; Oncology iMed, AstraZeneca, Alderley Park, Macclesfield SK10 4TG, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Ballard+P%22">Ballard P</searchLink><br /><searchLink fieldCode="AU" term="%22Buttar+D%22">Buttar D</searchLink><br /><searchLink fieldCode="AU" term="%22Crafter+C%22">Crafter C</searchLink><br /><searchLink fieldCode="AU" term="%22Currie+G%22">Currie G</searchLink><br /><searchLink fieldCode="AU" term="%22Davies+BR%22">Davies BR</searchLink><br /><searchLink fieldCode="AU" term="%22Debreczeni+J%22">Debreczeni J</searchLink><br /><searchLink fieldCode="AU" term="%22Dry+H%22">Dry H</searchLink><br /><searchLink fieldCode="AU" term="%22Dudley+P%22">Dudley P</searchLink><br /><searchLink fieldCode="AU" term="%22Greenwood+R%22">Greenwood R</searchLink><br /><searchLink fieldCode="AU" term="%22Johnson+PD%22">Johnson PD</searchLink><br /><searchLink fieldCode="AU" term="%22Kettle+JG%22">Kettle JG</searchLink><br /><searchLink fieldCode="AU" term="%22Lane+C%22">Lane C</searchLink><br /><searchLink fieldCode="AU" term="%22Lamont+G%22">Lamont G</searchLink><br /><searchLink fieldCode="AU" term="%22Leach+A%22">Leach A</searchLink><br /><searchLink fieldCode="AU" term="%22Luke+RW%22">Luke RW</searchLink><br /><searchLink fieldCode="AU" term="%22Morris+J%22">Morris J</searchLink><br /><searchLink fieldCode="AU" term="%22Ogilvie+D%22">Ogilvie D</searchLink><br /><searchLink fieldCode="AU" term="%22Page+K%22">Page K</searchLink><br /><searchLink fieldCode="AU" term="%22Pass+M%22">Pass M</searchLink><br /><searchLink fieldCode="AU" term="%22Pearson+S%22">Pearson S</searchLink><br /><searchLink fieldCode="AU" term="%22Ruston+L%22">Ruston L</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2013 Mar 14; Vol. 56 (5), pp. 2059-73. <i>Date of Electronic Publication: </i>2013 Feb 26. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=23394218 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1021/jm301762v Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 2059 Titles: – TitleFull: Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Addie M – PersonEntity: Name: NameFull: Ballard P – PersonEntity: Name: NameFull: Buttar D – PersonEntity: Name: NameFull: Crafter C – PersonEntity: Name: NameFull: Currie G – PersonEntity: Name: NameFull: Davies BR – PersonEntity: Name: NameFull: Debreczeni J – PersonEntity: Name: NameFull: Dry H – PersonEntity: Name: NameFull: Dudley P – PersonEntity: Name: NameFull: Greenwood R – PersonEntity: Name: NameFull: Johnson PD – PersonEntity: Name: NameFull: Kettle JG – PersonEntity: Name: NameFull: Lane C – PersonEntity: Name: NameFull: Lamont G – PersonEntity: Name: NameFull: Leach A – PersonEntity: Name: NameFull: Luke RW – PersonEntity: Name: NameFull: Morris J – PersonEntity: Name: NameFull: Ogilvie D – PersonEntity: Name: NameFull: Page K – PersonEntity: Name: NameFull: Pass M – PersonEntity: Name: NameFull: Pearson S – PersonEntity: Name: NameFull: Ruston L IsPartOfRelationships: – BibEntity: Dates: – D: 14 M: 03 Text: 2013 Mar 14 Type: published Y: 2013 Identifiers: – Type: issn-electronic Value: 1520-4804 Numbering: – Type: volume Value: 56 – Type: issue Value: 5 Titles: – TitleFull: Journal of medicinal chemistry Type: main |
| ResultId | 1 |
