Elucidation of the structural basis of interaction of the BCR-ABL kinase inhibitor, nilotinib (Tasigna) with the human ABC drug transporter P-glycoprotein.

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Title: Elucidation of the structural basis of interaction of the BCR-ABL kinase inhibitor, nilotinib (Tasigna) with the human ABC drug transporter P-glycoprotein.
Authors: Shukla S; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Chufan EE; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Singh S; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John's University, Queens, NY, USA., Skoumbourdis AP; NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, Rockville, MD, USA., Kapoor K; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Boxer MB; NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, Rockville, MD, USA., Duveau DY; NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, Rockville, MD, USA., Thomas CJ; NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, Rockville, MD, USA., Talele TT; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John's University, Queens, NY, USA., Ambudkar SV; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Source: Leukemia [Leukemia] 2014 Apr; Vol. 28 (4), pp. 961-4. Date of Electronic Publication: 2014 Jan 14.
Publication Type: Letter; Research Support, N.I.H., Intramural
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5551
DOI:10.1038/leu.2014.21