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Elimination of contaminating cap genes in AAV vector virions reduces immune responses and improves transgene expression in a canine gene therapy model.

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Title: Elimination of contaminating cap genes in AAV vector virions reduces immune responses and improves transgene expression in a canine gene therapy model.
Authors: Wang Z; 1] Program in Transplantation Biology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA [2] Department of Medicine, University of Washington, Seattle, WA, USA., Halbert CL; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Lee D; Department of Radiology, University of Washington, Seattle, WA, USA., Butts T; Program in Transplantation Biology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Tapscott SJ; 1] Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA [2] Department of Neurology, University of Washington, Seattle, WA, USA., Storb R; 1] Program in Transplantation Biology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA [2] Department of Medicine, University of Washington, Seattle, WA, USA., Miller AD; 1] Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA [2] Department of Pathology, University of Washington, Seattle, WA, USA.
Source: Gene therapy [Gene Ther] 2014 Apr; Vol. 21 (4), pp. 363-70. Date of Electronic Publication: 2014 Feb 06.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9421525 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5462 (Electronic) Linking ISSN: 09697128 NLM ISO Abbreviation: Gene Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5462
DOI:10.1038/gt.2014.4