Infant cynomolgus monkeys exposed to denosumab in utero exhibit an osteoclast-poor osteopetrotic-like skeletal phenotype at birth and in the early postnatal period.

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Title: Infant cynomolgus monkeys exposed to denosumab in utero exhibit an osteoclast-poor osteopetrotic-like skeletal phenotype at birth and in the early postnatal period.
Authors: Boyce RW; Department of Comparative Biology and Safety Sciences, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. Electronic address: rboyce@amgen.com., Varela A; Charles River Preclinical Services-Montreal, 22022 Transcanadienne, Senneville, QC H9X 3R3, Canada. Electronic address: aurore.varela@crl.com., Chouinard L; Charles River Preclinical Services-Montreal, 22022 Transcanadienne, Senneville, QC H9X 3R3, Canada. Electronic address: luc.chouinard@crl.com., Bussiere JL; Department of Comparative Biology and Safety Sciences, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. Electronic address: bussierj@amgen.com., Chellman GJ; Charles River Preclinical Services-Nevada, 6995 Longley Lane, Reno, NV 89511, USA. Electronic address: gary.chellman@crl.com., Ominsky MS; Department of Metabolic Disorders, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. Electronic address: mominsky@amgen.com., Pyrah IT; Department of Comparative Biology and Safety Sciences, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. Electronic address: ipyrah@amgen.com.
Source: Bone [Bone] 2014 Jul; Vol. 64, pp. 314-25. Date of Electronic Publication: 2014 Apr 13.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8504048 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2763 (Electronic) Linking ISSN: 18732763 NLM ISO Abbreviation: Bone Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1873-2763
DOI:10.1016/j.bone.2014.04.002