Infant cynomolgus monkeys exposed to denosumab in utero exhibit an osteoclast-poor osteopetrotic-like skeletal phenotype at birth and in the early postnatal period.

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Title: Infant cynomolgus monkeys exposed to denosumab in utero exhibit an osteoclast-poor osteopetrotic-like skeletal phenotype at birth and in the early postnatal period.
Authors: Boyce RW; Department of Comparative Biology and Safety Sciences, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. Electronic address: rboyce@amgen.com., Varela A; Charles River Preclinical Services-Montreal, 22022 Transcanadienne, Senneville, QC H9X 3R3, Canada. Electronic address: aurore.varela@crl.com., Chouinard L; Charles River Preclinical Services-Montreal, 22022 Transcanadienne, Senneville, QC H9X 3R3, Canada. Electronic address: luc.chouinard@crl.com., Bussiere JL; Department of Comparative Biology and Safety Sciences, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. Electronic address: bussierj@amgen.com., Chellman GJ; Charles River Preclinical Services-Nevada, 6995 Longley Lane, Reno, NV 89511, USA. Electronic address: gary.chellman@crl.com., Ominsky MS; Department of Metabolic Disorders, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. Electronic address: mominsky@amgen.com., Pyrah IT; Department of Comparative Biology and Safety Sciences, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. Electronic address: ipyrah@amgen.com.
Source: Bone [Bone] 2014 Jul; Vol. 64, pp. 314-25. Date of Electronic Publication: 2014 Apr 13.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8504048 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2763 (Electronic) Linking ISSN: 18732763 NLM ISO Abbreviation: Bone Subsets: MEDLINE
Database: MEDLINE Ultimate
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An: 24727159
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PubType: Academic Journal
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  Data: Infant cynomolgus monkeys exposed to denosumab in utero exhibit an osteoclast-poor osteopetrotic-like skeletal phenotype at birth and in the early postnatal period.
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  Data: <searchLink fieldCode="AU" term="%22Boyce+RW%22">Boyce RW</searchLink>; Department of Comparative Biology and Safety Sciences, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. Electronic address: rboyce@amgen.com.<br /><searchLink fieldCode="AU" term="%22Varela+A%22">Varela A</searchLink>; Charles River Preclinical Services-Montreal, 22022 Transcanadienne, Senneville, QC H9X 3R3, Canada. Electronic address: aurore.varela@crl.com.<br /><searchLink fieldCode="AU" term="%22Chouinard+L%22">Chouinard L</searchLink>; Charles River Preclinical Services-Montreal, 22022 Transcanadienne, Senneville, QC H9X 3R3, Canada. Electronic address: luc.chouinard@crl.com.<br /><searchLink fieldCode="AU" term="%22Bussiere+JL%22">Bussiere JL</searchLink>; Department of Comparative Biology and Safety Sciences, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. Electronic address: bussierj@amgen.com.<br /><searchLink fieldCode="AU" term="%22Chellman+GJ%22">Chellman GJ</searchLink>; Charles River Preclinical Services-Nevada, 6995 Longley Lane, Reno, NV 89511, USA. Electronic address: gary.chellman@crl.com.<br /><searchLink fieldCode="AU" term="%22Ominsky+MS%22">Ominsky MS</searchLink>; Department of Metabolic Disorders, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. Electronic address: mominsky@amgen.com.<br /><searchLink fieldCode="AU" term="%22Pyrah+IT%22">Pyrah IT</searchLink>; Department of Comparative Biology and Safety Sciences, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. Electronic address: ipyrah@amgen.com.
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  Data: <searchLink fieldCode="JN" term="%228504048%22">Bone</searchLink> [Bone] 2014 Jul; Vol. 64, pp. 314-25. <i>Date of Electronic Publication: </i>2014 Apr 13.
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  Data: Journal Article; Research Support, Non-U.S. Gov't
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8504048 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-2763 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2218732763%22">18732763 </searchLink><i>NLM ISO Abbreviation: </i>Bone <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.bone.2014.04.002
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      – Code: eng
        Text: English
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      – TitleFull: Infant cynomolgus monkeys exposed to denosumab in utero exhibit an osteoclast-poor osteopetrotic-like skeletal phenotype at birth and in the early postnatal period.
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              Text: 2014 Jul
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