An integrin β₃-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition.

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Title: An integrin β₃-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition.
Authors: Seguin L; Department of Pathology and Moores UCSD Cancer Center, University of California, San Diego, La Jolla, California 92093, USA., Kato S; School of Medicine, Division of Hematology/Oncology, University of California, San Diego, La Jolla, California 92093, USA., Franovic A; Department of Pathology and Moores UCSD Cancer Center, University of California, San Diego, La Jolla, California 92093, USA., Camargo MF; Department of Pathology and Moores UCSD Cancer Center, University of California, San Diego, La Jolla, California 92093, USA., Lesperance J; Department of Pathology and Moores UCSD Cancer Center, University of California, San Diego, La Jolla, California 92093, USA., Elliott KC; Department of Pathology and Moores UCSD Cancer Center, University of California, San Diego, La Jolla, California 92093, USA., Yebra M; Department of Pathology and Moores UCSD Cancer Center, University of California, San Diego, La Jolla, California 92093, USA., Mielgo A; Department of Pathology and Moores UCSD Cancer Center, University of California, San Diego, La Jolla, California 92093, USA., Lowy AM; Division of Surgical Oncology, Departments of Surgery, San Diego, La Jolla, California 92093, USA., Husain H; School of Medicine, Division of Hematology/Oncology, University of California, San Diego, La Jolla, California 92093, USA., Cascone T; Departments of Thoracic/Head and Neck Medical Oncology and Cancer Biology, The University of Texas, MD Anderson Cancer Center, Houston, Texas 77030, USA., Diao L; Departments of Thoracic/Head and Neck Medical Oncology and Cancer Biology, The University of Texas, MD Anderson Cancer Center, Houston, Texas 77030, USA., Wang J; Departments of Thoracic/Head and Neck Medical Oncology and Cancer Biology, The University of Texas, MD Anderson Cancer Center, Houston, Texas 77030, USA., Wistuba II; Departments of Thoracic/Head and Neck Medical Oncology and Cancer Biology, The University of Texas, MD Anderson Cancer Center, Houston, Texas 77030, USA., Heymach JV; Departments of Thoracic/Head and Neck Medical Oncology and Cancer Biology, The University of Texas, MD Anderson Cancer Center, Houston, Texas 77030, USA., Lippman SM; Moores UCSD Cancer Center, University of California, San Diego, La Jolla, California 92093, USA., Desgrosellier JS; Department of Pathology and Moores UCSD Cancer Center, University of California, San Diego, La Jolla, California 92093, USA., Anand S; Department of Pathology and Moores UCSD Cancer Center, University of California, San Diego, La Jolla, California 92093, USA., Weis SM; Department of Pathology and Moores UCSD Cancer Center, University of California, San Diego, La Jolla, California 92093, USA., Cheresh DA; Department of Pathology and Moores UCSD Cancer Center, University of California, San Diego, La Jolla, California 92093, USA.
Source: Nature cell biology [Nat Cell Biol] 2014 May; Vol. 16 (5), pp. 457-68. Date of Electronic Publication: 2014 Apr 20.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-4679
DOI:10.1038/ncb2953