Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor.
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| Title: | Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor. |
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| Authors: | Harper S; Departments of Medicinal Chemistry, Drug Metabolism, and Molecular Modeling, IRBM, Merck Research Laboratories , Rome, Italy., McCauley JA; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., Rudd MT; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., Ferrara M; Departments of Medicinal Chemistry, Drug Metabolism, and Molecular Modeling, IRBM, Merck Research Laboratories , Rome, Italy., DiFilippo M; Departments of Medicinal Chemistry, Drug Metabolism, and Molecular Modeling, IRBM, Merck Research Laboratories , Rome, Italy., Crescenzi B; Departments of Medicinal Chemistry, Drug Metabolism, and Molecular Modeling, IRBM, Merck Research Laboratories , Rome, Italy., Koch U; Departments of Medicinal Chemistry, Drug Metabolism, and Molecular Modeling, IRBM, Merck Research Laboratories , Rome, Italy., Petrocchi A; Departments of Medicinal Chemistry, Drug Metabolism, and Molecular Modeling, IRBM, Merck Research Laboratories , Rome, Italy., Holloway MK; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., Butcher JW; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., Romano JJ; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., Bush KJ; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., Gilbert KF; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., McIntyre CJ; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., Nguyen KT; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., Nizi E; Departments of Medicinal Chemistry, Drug Metabolism, and Molecular Modeling, IRBM, Merck Research Laboratories , Rome, Italy., Carroll SS; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., Ludmerer SW; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., Burlein C; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., DiMuzio JM; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., Graham DJ; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., McHale CM; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., Stahlhut MW; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., Olsen DB; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., Monteagudo E; Departments of Medicinal Chemistry, Drug Metabolism, and Molecular Modeling, IRBM, Merck Research Laboratories , Rome, Italy., Cianetti S; Departments of Medicinal Chemistry, Drug Metabolism, and Molecular Modeling, IRBM, Merck Research Laboratories , Rome, Italy., Giuliano C; Departments of Medicinal Chemistry, Drug Metabolism, and Molecular Modeling, IRBM, Merck Research Laboratories , Rome, Italy., Pucci V; Departments of Medicinal Chemistry, Drug Metabolism, and Molecular Modeling, IRBM, Merck Research Laboratories , Rome, Italy., Trainor N; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., Fandozzi CM; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., Rowley M; Departments of Medicinal Chemistry, Drug Metabolism, and Molecular Modeling, IRBM, Merck Research Laboratories , Rome, Italy., Coleman PJ; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., Vacca JP; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., Summa V; Departments of Medicinal Chemistry, Drug Metabolism, and Molecular Modeling, IRBM, Merck Research Laboratories , Rome, Italy., Liverton NJ; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States. |
| Source: | ACS medicinal chemistry letters [ACS Med Chem Lett] 2012 Mar 02; Vol. 3 (4), pp. 332-6. Date of Electronic Publication: 2012 Mar 02 (Print Publication: 2012). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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