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Optimization of a Novel Series of TRPV4 Antagonists with In Vivo Activity in a Model of Pulmonary Edema.

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Bibliographic Details
Title: Optimization of a Novel Series of TRPV4 Antagonists with In Vivo Activity in a Model of Pulmonary Edema.
Authors: Hilfiker MA; Departments of Chemistry, Biology, and Drug Metabolism and Pharmacokinetics, Metabolic Pathways and Cardiovascular Therapeutic Area Unit, GlaxoSmithKline , 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States., Hoang TH; Departments of Chemistry, Biology, and Drug Metabolism and Pharmacokinetics, Metabolic Pathways and Cardiovascular Therapeutic Area Unit, GlaxoSmithKline , 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States., Cornil J; Departments of Chemistry, Biology, and Drug Metabolism and Pharmacokinetics, Metabolic Pathways and Cardiovascular Therapeutic Area Unit, GlaxoSmithKline , 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States., Eidam HS; Departments of Chemistry, Biology, and Drug Metabolism and Pharmacokinetics, Metabolic Pathways and Cardiovascular Therapeutic Area Unit, GlaxoSmithKline , 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States., Matasic DS; Departments of Chemistry, Biology, and Drug Metabolism and Pharmacokinetics, Metabolic Pathways and Cardiovascular Therapeutic Area Unit, GlaxoSmithKline , 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States., Roethke TJ; Departments of Chemistry, Biology, and Drug Metabolism and Pharmacokinetics, Metabolic Pathways and Cardiovascular Therapeutic Area Unit, GlaxoSmithKline , 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States., Klein M; Platform Technology and Science, Molecular Discovery Research, GlaxoSmithKline , 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Thorneloe KS; Departments of Chemistry, Biology, and Drug Metabolism and Pharmacokinetics, Metabolic Pathways and Cardiovascular Therapeutic Area Unit, GlaxoSmithKline , 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States., Cheung M; Departments of Chemistry, Biology, and Drug Metabolism and Pharmacokinetics, Metabolic Pathways and Cardiovascular Therapeutic Area Unit, GlaxoSmithKline , 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States.
Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2013 Jan 27; Vol. 4 (2), pp. 293-6. Date of Electronic Publication: 2013 Jan 27 (Print Publication: 2013).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1948-5875
DOI:10.1021/ml300449k