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KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission.

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Title: KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission.
Authors: Kuhen KL; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA., Chatterjee AK; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA., Rottmann M; Swiss Tropical and Public Health Institute, Parasite Chemotherapy, Basel, Switzerland University of Basel, Basel, Switzerland., Gagaring K; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA., Borboa R; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA., Buenviaje J; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA., Chen Z; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA., Francek C; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA., Wu T; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA., Nagle A; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA., Barnes SW; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA., Plouffe D; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA., Lee MC; Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, New York, USA., Fidock DA; Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, New York, USA Division of Infectious Diseases, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA., Graumans W; Radboud University Nijmegen Medical Center, Medical Microbiology Department, Nijmegen, The Netherlands., van de Vegte-Bolmer M; Radboud University Nijmegen Medical Center, Medical Microbiology Department, Nijmegen, The Netherlands., van Gemert GJ; Radboud University Nijmegen Medical Center, Medical Microbiology Department, Nijmegen, The Netherlands., Wirjanata G; Global Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia., Sebayang B; Eijkman Institute for Molecular Biology, Jakarta, Indonesia., Marfurt J; Global Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia., Russell B; Laboratory of Malaria Immunobiology, Singapore Immunology Network, Agency for Science Technology and Research, Biopolis, Singapore., Suwanarusk R; Laboratory of Malaria Immunobiology, Singapore Immunology Network, Agency for Science Technology and Research, Biopolis, Singapore., Price RN; Global Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom., Nosten F; Shoklo Malaria Research Unit, Mae Sot, Tak, Thailand Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom., Tungtaeng A; Department of Veterinary Medicine, U.S. Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand., Gettayacamin M; Department of Veterinary Medicine, U.S. Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand., Sattabongkot J; Entomology Department, AFRIMS, Bangkok, Thailand Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., Taylor J; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA., Walker JR; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA., Tully D; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA., Patra KP; Division of Infectious Diseases, Department of Medicine, University of California, San Diego, La Jolla, California, USA., Flannery EL; Division of Pharmacology and Drug Discovery, University of California, San Diego, School of Medicine, La Jolla, California, USA., Vinetz JM; Division of Infectious Diseases, Department of Medicine, University of California, San Diego, La Jolla, California, USA., Renia L; Laboratory of Malaria Immunobiology, Singapore Immunology Network, Agency for Science Technology and Research, Biopolis, Singapore., Sauerwein RW; Radboud University Nijmegen Medical Center, Medical Microbiology Department, Nijmegen, The Netherlands., Winzeler EA; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA Division of Pharmacology and Drug Discovery, University of California, San Diego, School of Medicine, La Jolla, California, USA., Glynne RJ; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA., Diagana TT; Novartis Institute for Tropical Diseases, Singapore thierry.diagana@novartis.com.
Source: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2014 Sep; Vol. 58 (9), pp. 5060-7. Date of Electronic Publication: 2014 Jun 09.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission.
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  Data: <searchLink fieldCode="AU" term="%22Kuhen+KL%22">Kuhen KL</searchLink>; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Chatterjee+AK%22">Chatterjee AK</searchLink>; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Rottmann+M%22">Rottmann M</searchLink>; Swiss Tropical and Public Health Institute, Parasite Chemotherapy, Basel, Switzerland University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Gagaring+K%22">Gagaring K</searchLink>; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Borboa+R%22">Borboa R</searchLink>; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Buenviaje+J%22">Buenviaje J</searchLink>; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Francek+C%22">Francek C</searchLink>; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Wu+T%22">Wu T</searchLink>; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Nagle+A%22">Nagle A</searchLink>; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Barnes+SW%22">Barnes SW</searchLink>; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Plouffe+D%22">Plouffe D</searchLink>; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Lee+MC%22">Lee MC</searchLink>; Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Fidock+DA%22">Fidock DA</searchLink>; Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, New York, USA Division of Infectious Diseases, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Graumans+W%22">Graumans W</searchLink>; Radboud University Nijmegen Medical Center, Medical Microbiology Department, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+de+Vegte-Bolmer+M%22">van de Vegte-Bolmer M</searchLink>; Radboud University Nijmegen Medical Center, Medical Microbiology Department, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Gemert+GJ%22">van Gemert GJ</searchLink>; Radboud University Nijmegen Medical Center, Medical Microbiology Department, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Wirjanata+G%22">Wirjanata G</searchLink>; Global Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia.<br /><searchLink fieldCode="AU" term="%22Sebayang+B%22">Sebayang B</searchLink>; Eijkman Institute for Molecular Biology, Jakarta, Indonesia.<br /><searchLink fieldCode="AU" term="%22Marfurt+J%22">Marfurt J</searchLink>; Global Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia.<br /><searchLink fieldCode="AU" term="%22Russell+B%22">Russell B</searchLink>; Laboratory of Malaria Immunobiology, Singapore Immunology Network, Agency for Science Technology and Research, Biopolis, Singapore.<br /><searchLink fieldCode="AU" term="%22Suwanarusk+R%22">Suwanarusk R</searchLink>; Laboratory of Malaria Immunobiology, Singapore Immunology Network, Agency for Science Technology and Research, Biopolis, Singapore.<br /><searchLink fieldCode="AU" term="%22Price+RN%22">Price RN</searchLink>; Global Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Nosten+F%22">Nosten F</searchLink>; Shoklo Malaria Research Unit, Mae Sot, Tak, Thailand Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Tungtaeng+A%22">Tungtaeng A</searchLink>; Department of Veterinary Medicine, U.S. Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Gettayacamin+M%22">Gettayacamin M</searchLink>; Department of Veterinary Medicine, U.S. Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Sattabongkot+J%22">Sattabongkot J</searchLink>; Entomology Department, AFRIMS, Bangkok, Thailand Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Taylor+J%22">Taylor J</searchLink>; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Walker+JR%22">Walker JR</searchLink>; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Tully+D%22">Tully D</searchLink>; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Patra+KP%22">Patra KP</searchLink>; Division of Infectious Diseases, Department of Medicine, University of California, San Diego, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Flannery+EL%22">Flannery EL</searchLink>; Division of Pharmacology and Drug Discovery, University of California, San Diego, School of Medicine, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Vinetz+JM%22">Vinetz JM</searchLink>; Division of Infectious Diseases, Department of Medicine, University of California, San Diego, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Renia+L%22">Renia L</searchLink>; Laboratory of Malaria Immunobiology, Singapore Immunology Network, Agency for Science Technology and Research, Biopolis, Singapore.<br /><searchLink fieldCode="AU" term="%22Sauerwein+RW%22">Sauerwein RW</searchLink>; Radboud University Nijmegen Medical Center, Medical Microbiology Department, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Winzeler+EA%22">Winzeler EA</searchLink>; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA Division of Pharmacology and Drug Discovery, University of California, San Diego, School of Medicine, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Glynne+RJ%22">Glynne RJ</searchLink>; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Diagana+TT%22">Diagana TT</searchLink>; Novartis Institute for Tropical Diseases, Singapore thierry.diagana@novartis.com.
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  Data: <searchLink fieldCode="JN" term="%220315061%22">Antimicrobial agents and chemotherapy</searchLink> [Antimicrob Agents Chemother] 2014 Sep; Vol. 58 (9), pp. 5060-7. <i>Date of Electronic Publication: </i>2014 Jun 09.
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