An anti-neuroinflammatory that targets dysregulated glia enhances the efficacy of CNS-directed gene therapy in murine infantile neuronal ceroid lipofuscinosis.

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Title: An anti-neuroinflammatory that targets dysregulated glia enhances the efficacy of CNS-directed gene therapy in murine infantile neuronal ceroid lipofuscinosis.
Authors: Macauley SL; Department of Neurology, Department of Internal Medicine, and., Wong AM; Department of Neuroscience, Centre for the Cellular Basis of Behaviour, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King's College London, London SE5 9NU, United Kingdom, and., Shyng C; Department of Internal Medicine, and., Augner DP; Department of Neuroscience, Centre for the Cellular Basis of Behaviour, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King's College London, London SE5 9NU, United Kingdom, and., Dearborn JT; Department of Internal Medicine, and., Pearse Y; Department of Neuroscience, Centre for the Cellular Basis of Behaviour, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King's College London, London SE5 9NU, United Kingdom, and., Roberts MS; Department of Internal Medicine, and., Fowler SC; Departments of Pharmacology and Toxicology, University of Kansas, Lawrence, Kansas 66045., Cooper JD; Department of Neuroscience, Centre for the Cellular Basis of Behaviour, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King's College London, London SE5 9NU, United Kingdom, and., Watterson DM; Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611., Sands MS; Department of Internal Medicine, and Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110, msands@dom.wustl.edu.
Source: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2014 Sep 24; Vol. 34 (39), pp. 13077-82.
Publication Type: Journal Article
Journal Info: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Print Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1529-2401
DOI:10.1523/JNEUROSCI.2518-14.2014