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A phase IB trial of the oral MEK inhibitor trametinib (GSK1120212) in combination with everolimus in patients with advanced solid tumors.

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Title: A phase IB trial of the oral MEK inhibitor trametinib (GSK1120212) in combination with everolimus in patients with advanced solid tumors.
Authors: Tolcher AW; South Texas Accelerated Research Therapeutics LLC, San Antonio. Electronic address: atolcher@start.stoh.com., Bendell JC; Sarah Cannon Research Institute/Tennessee Oncology, PLLC, Nashville., Papadopoulos KP; South Texas Accelerated Research Therapeutics LLC, San Antonio., Burris HA 3rd; Sarah Cannon Research Institute/Tennessee Oncology, PLLC, Nashville., Patnaik A; South Texas Accelerated Research Therapeutics LLC, San Antonio., Jones SF; Sarah Cannon Research Institute/Tennessee Oncology, PLLC, Nashville., Rasco D; South Texas Accelerated Research Therapeutics LLC, San Antonio., Cox DS; GlaxoSmithKline, Collegeville., Durante M; GlaxoSmithKline, Collegeville., Bellew KM; Pharmaceutical Companies of Johnson and Johnson, Greater Philadelphia Area., Park J; GlaxoSmithKline, Collegeville., Le NT; Novartis, East Hanover, USA., Infante JR; Sarah Cannon Research Institute/Tennessee Oncology, PLLC, Nashville.
Source: Annals of oncology : official journal of the European Society for Medical Oncology [Ann Oncol] 2015 Jan; Vol. 26 (1), pp. 58-64. Date of Electronic Publication: 2014 Oct 24.
Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 9007735 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1569-8041 (Electronic) Linking ISSN: 09237534 NLM ISO Abbreviation: Ann Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
An: 25344362
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: A phase IB trial of the oral MEK inhibitor trametinib (GSK1120212) in combination with everolimus in patients with advanced solid tumors.
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  Data: <searchLink fieldCode="AU" term="%22Tolcher+AW%22">Tolcher AW</searchLink>; South Texas Accelerated Research Therapeutics LLC, San Antonio. Electronic address: atolcher@start.stoh.com.<br /><searchLink fieldCode="AU" term="%22Bendell+JC%22">Bendell JC</searchLink>; Sarah Cannon Research Institute/Tennessee Oncology, PLLC, Nashville.<br /><searchLink fieldCode="AU" term="%22Papadopoulos+KP%22">Papadopoulos KP</searchLink>; South Texas Accelerated Research Therapeutics LLC, San Antonio.<br /><searchLink fieldCode="AU" term="%22Burris+HA+3rd%22">Burris HA 3rd</searchLink>; Sarah Cannon Research Institute/Tennessee Oncology, PLLC, Nashville.<br /><searchLink fieldCode="AU" term="%22Patnaik+A%22">Patnaik A</searchLink>; South Texas Accelerated Research Therapeutics LLC, San Antonio.<br /><searchLink fieldCode="AU" term="%22Jones+SF%22">Jones SF</searchLink>; Sarah Cannon Research Institute/Tennessee Oncology, PLLC, Nashville.<br /><searchLink fieldCode="AU" term="%22Rasco+D%22">Rasco D</searchLink>; South Texas Accelerated Research Therapeutics LLC, San Antonio.<br /><searchLink fieldCode="AU" term="%22Cox+DS%22">Cox DS</searchLink>; GlaxoSmithKline, Collegeville.<br /><searchLink fieldCode="AU" term="%22Durante+M%22">Durante M</searchLink>; GlaxoSmithKline, Collegeville.<br /><searchLink fieldCode="AU" term="%22Bellew+KM%22">Bellew KM</searchLink>; Pharmaceutical Companies of Johnson and Johnson, Greater Philadelphia Area.<br /><searchLink fieldCode="AU" term="%22Park+J%22">Park J</searchLink>; GlaxoSmithKline, Collegeville.<br /><searchLink fieldCode="AU" term="%22Le+NT%22">Le NT</searchLink>; Novartis, East Hanover, USA.<br /><searchLink fieldCode="AU" term="%22Infante+JR%22">Infante JR</searchLink>; Sarah Cannon Research Institute/Tennessee Oncology, PLLC, Nashville.
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  Data: <searchLink fieldCode="JN" term="%229007735%22">Annals of oncology : official journal of the European Society for Medical Oncology</searchLink> [Ann Oncol] 2015 Jan; Vol. 26 (1), pp. 58-64. <i>Date of Electronic Publication: </i>2014 Oct 24.
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  Data: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9007735 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1569-8041 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209237534%22">09237534 </searchLink><i>NLM ISO Abbreviation: </i>Ann Oncol <i>Subsets: </i>MEDLINE
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              Text: 2015 Jan
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