OX40- and CD27-mediated costimulation synergizes with anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence.

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Title: OX40- and CD27-mediated costimulation synergizes with anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence.
Authors: Buchan S; Cancer Sciences Unit, Faculty of Medicine, University of Southampton., Manzo T; Transplantation Immunology Group, Cancer Institute and Institute for Immunity and Transplantation, University College London., Flutter B; Transplantation Immunology Group, Cancer Institute and Institute for Immunity and Transplantation, University College London., Rogel A; Cancer Sciences Unit, Faculty of Medicine, University of Southampton., Edwards N; Transplantation Immunology Group, Cancer Institute and Institute for Immunity and Transplantation, University College London., Zhang L; Transplantation Immunology Group, Cancer Institute and Institute for Immunity and Transplantation, University College London., Sivakumaran S; Transplantation Immunology Group, Cancer Institute and Institute for Immunity and Transplantation, University College London., Ghorashian S; Transplantation Immunology Group, Cancer Institute and Institute for Immunity and Transplantation, University College London., Carpenter B; Transplantation Immunology Group, Cancer Institute and Institute for Immunity and Transplantation, University College London., Bennett C; Transplantation Immunology Group, Cancer Institute and Institute for Immunity and Transplantation, University College London., Freeman GJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School., Sykes M; Columbia Center for Translational Immunology, Columbia University Medical Center, New York., Croft M; Institute of Allergy and Immunology, La Jolla., Al-Shamkhani A; Cancer Sciences Unit, Faculty of Medicine, University of Southampton., Chakraverty R; Transplantation Immunology Group, Cancer Institute and Institute for Immunity and Transplantation, University College London.
Source: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2015 Jan 01; Vol. 194 (1), pp. 125-133. Date of Electronic Publication: 2014 Nov 17.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 2985117R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1550-6606 (Electronic) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1550-6606
DOI:10.4049/jimmunol.1401644