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Comparative Localization and Functional Activity of the Main Hepatobiliary Transporters in HepaRG Cells and Primary Human Hepatocytes.

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Title: Comparative Localization and Functional Activity of the Main Hepatobiliary Transporters in HepaRG Cells and Primary Human Hepatocytes.
Authors: Bachour-El Azzi P; Inserm UMR991, Foie, Métabolismes et Cancer, Rennes, France; Université de Rennes 1, Rennes, France, Université Libanaise, EDST-PRASE and EDST-AZM-center-LBA3B, Beirut, Lebanon, Biopredic International, Saint Grégoire, France, ImPACcell, SFR Biosit, Université de Rennes 1, Rennes, France and Department of Clinical Pharmacology and Toxicology, University Hospital, Zurich, Switzerland *Inserm UMR991, Foie, Métabolismes et Cancer, Rennes, France; Université de Rennes 1, Rennes, France, Université Libanaise, EDST-PRASE and EDST-AZM-center-LBA3B, Beirut, Lebanon, Biopredic International, Saint Grégoire, France, ImPACcell, SFR Biosit, Université de Rennes 1, Rennes, France and Department of Clinical Pharmacology and Toxicology, University Hospital, Zurich, Switzerland *Inserm UMR991, Foie, Métabolismes et Cancer, Rennes, France; Université de Rennes 1, Rennes, France, Université Libanaise, EDST-PRASE and EDST-AZM-center-LBA3B, Beirut, Lebanon, Biopredic International, Saint Grégoire, France, ImPACcell, SFR Biosit, Université de Rennes 1, Rennes, France and Department of Clinical Pharmacology and Toxicology, University Hospital, Zurich, Switzerland., Sharanek A; Inserm UMR991, Foie, Métabolismes et Cancer, Rennes, France; Université de Rennes 1, Rennes, France, Université Libanaise, EDST-PRASE and EDST-AZM-center-LBA3B, Beirut, Lebanon, Biopredic International, Saint Grégoire, France, ImPACcell, SFR Biosit, Université de Rennes 1, Rennes, France and Department of Clinical Pharmacology and Toxicology, University Hospital, Zurich, Switzerland *Inserm UMR991, Foie, Métabolismes et Cancer, Rennes, France; Université de Rennes 1, Rennes, France, Université Libanaise, EDST-PRASE and EDST-AZM-center-LBA3B, Beirut, Lebanon, Biopredic International, Saint Grégoire, France, ImPACcell, SFR Biosit, Université de Rennes 1, Rennes, France and Department of Clinical Pharmacology and Toxicology, University Hospital, Zurich, Switzerland., Burban A; Inserm UMR991, Foie, Métabolismes et Cancer, Rennes, France; Université de Rennes 1, Rennes, France, Université Libanaise, EDST-PRASE and EDST-AZM-center-LBA3B, Beirut, Lebanon, Biopredic International, Saint Grégoire, France, ImPACcell, SFR Biosit, Université de Rennes 1, Rennes, France and Department of Clinical Pharmacology and Toxicology, University Hospital, Zurich, Switzerland *Inserm UMR991, Foie, Métabolismes et Cancer, Rennes, France; Université de Rennes 1, Rennes, France, Université Libanaise, EDST-PRASE and EDST-AZM-center-LBA3B, Beirut, Lebanon, Biopredic International, Saint Grégoire, France, ImPACcell, SFR Biosit, Université de Rennes 1, Rennes, France and Department of Clinical Pharmacology and Toxicology, University Hospital, Zurich, Switzerland., Li R; Inserm UMR991, Foie, Métabolismes et Cancer, Rennes, France; Université de Rennes 1, Rennes, France, Université Libanaise, EDST-PRASE and EDST-AZM-center-LBA3B, Beirut, Lebanon, Biopredic International, Saint Grégoire, France, ImPACcell, SFR Biosit, Université de Rennes 1, Rennes, France and Department of Clinical Pharmacology and Toxicology, University Hospital, Zurich, Switzerland., Guével RL; Inserm UMR991, Foie, Métabolismes et Cancer, Rennes, France; Université de Rennes 1, Rennes, France, Université Libanaise, EDST-PRASE and EDST-AZM-center-LBA3B, Beirut, Lebanon, Biopredic International, Saint Grégoire, France, ImPACcell, SFR Biosit, Université de Rennes 1, Rennes, France and Department of Clinical Pharmacology and Toxicology, University Hospital, Zurich, Switzerland., Abdel-Razzak Z; Inserm UMR991, Foie, Métabolismes et Cancer, Rennes, France; Université de Rennes 1, Rennes, France, Université Libanaise, EDST-PRASE and EDST-AZM-center-LBA3B, Beirut, Lebanon, Biopredic International, Saint Grégoire, France, ImPACcell, SFR Biosit, Université de Rennes 1, Rennes, France and Department of Clinical Pharmacology and Toxicology, University Hospital, Zurich, Switzerland., Stieger B; Inserm UMR991, Foie, Métabolismes et Cancer, Rennes, France; Université de Rennes 1, Rennes, France, Université Libanaise, EDST-PRASE and EDST-AZM-center-LBA3B, Beirut, Lebanon, Biopredic International, Saint Grégoire, France, ImPACcell, SFR Biosit, Université de Rennes 1, Rennes, France and Department of Clinical Pharmacology and Toxicology, University Hospital, Zurich, Switzerland *Inserm UMR991, Foie, Métabolismes et Cancer, Rennes, France; Université de Rennes 1, Rennes, France, Université Libanaise, EDST-PRASE and EDST-AZM-center-LBA3B, Beirut, Lebanon, Biopredic International, Saint Grégoire, France, ImPACcell, SFR Biosit, Université de Rennes 1, Rennes, France and Department of Clinical Pharmacology and Toxicology, University Hospital, Zurich, Switzerland., Guguen-Guillouzo C; Inserm UMR991, Foie, Métabolismes et Cancer, Rennes, France; Université de Rennes 1, Rennes, France, Université Libanaise, EDST-PRASE and EDST-AZM-center-LBA3B, Beirut, Lebanon, Biopredic International, Saint Grégoire, France, ImPACcell, SFR Biosit, Université de Rennes 1, Rennes, France and Department of Clinical Pharmacology and Toxicology, University Hospital, Zurich, Switzerland., Guillouzo A; Inserm UMR991, Foie, Métabolismes et Cancer, Rennes, France; Université de Rennes 1, Rennes, France, Université Libanaise, EDST-PRASE and EDST-AZM-center-LBA3B, Beirut, Lebanon, Biopredic International, Saint Grégoire, France, ImPACcell, SFR Biosit, Université de Rennes 1, Rennes, France and Department of Clinical Pharmacology and Toxicology, University Hospital, Zurich, Switzerland *Inserm UMR991, Foie, Métabolismes et Cancer, Rennes, France; Université de Rennes 1, Rennes, France, Université Libanaise, EDST-PRASE and EDST-AZM-center-LBA3B, Beirut, Lebanon, Biopredic International, Saint Grégoire, France, ImPACcell, SFR Biosit, Université de Rennes 1, Rennes, France and Department of Clinical Pharmacology and Toxicology, University Hospital, Zurich, Switzerland andre.guillouzo@univ-rennes1.fr.
Source: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2015 May; Vol. 145 (1), pp. 157-68. Date of Electronic Publication: 2015 Feb 17.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 9805461 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0929 (Electronic) Linking ISSN: 10960929 NLM ISO Abbreviation: Toxicol Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1096-0929
DOI:10.1093/toxsci/kfv041