Aberrant splicing in transgenes containing introns, exons, and V5 epitopes: lessons from developing an FSHD mouse model expressing a D4Z4 repeat with flanking genomic sequences.

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Title: Aberrant splicing in transgenes containing introns, exons, and V5 epitopes: lessons from developing an FSHD mouse model expressing a D4Z4 repeat with flanking genomic sequences.
Authors: Ansseau E; University of Mons, Research Institute for Health Sciences and Technology, Laboratory of Molecular Biology, Mons, Belgium., Domire JS; Center for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, OH, United States of America., Wallace LM; Center for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, OH, United States of America., Eidahl JO; Center for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, OH, United States of America., Guckes SM; Center for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, OH, United States of America., Giesige CR; Center for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, OH, United States of America; Biomedical Sciences Graduate Program, The Ohio State University, Columbus, OH, United States of America., Pyne NK; Center for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, OH, United States of America., Belayew A; University of Mons, Research Institute for Health Sciences and Technology, Laboratory of Molecular Biology, Mons, Belgium., Harper SQ; Center for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, OH, United States of America; Biomedical Sciences Graduate Program, The Ohio State University, Columbus, OH, United States of America; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, United States of America.
Source: PloS one [PLoS One] 2015 Mar 05; Vol. 10 (3), pp. e0118813. Date of Electronic Publication: 2015 Mar 05 (Print Publication: 2015).
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1932-6203
DOI:10.1371/journal.pone.0118813