Hitting the right spot: Mechanism of action of OPB-31121, a novel and potent inhibitor of the Signal Transducer and Activator of Transcription 3 (STAT3).

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Title: Hitting the right spot: Mechanism of action of OPB-31121, a novel and potent inhibitor of the Signal Transducer and Activator of Transcription 3 (STAT3).
Authors: Brambilla L; Institute of Oncology Research (IOR), Via Vela 6, 6500 Bellinzona, Switzerland., Genini D; Institute of Oncology Research (IOR), Via Vela 6, 6500 Bellinzona, Switzerland., Laurini E; Molecular Simulation Laboratory (MOSE), University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy., Merulla J; Institute of Oncology Research (IOR), Via Vela 6, 6500 Bellinzona, Switzerland., Perez L; Institute of Research in Biomedicine (IRB), Via Vela 6, 6500 Bellinzona, Switzerland., Fermeglia M; Molecular Simulation Laboratory (MOSE), University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy., Carbone GM; Institute of Oncology Research (IOR), Via Vela 6, 6500 Bellinzona, Switzerland; Oncology Institute of Southern Switzerland (IOSI), Via Vela 6, 6500 Bellinzona, Switzerland., Pricl S; Molecular Simulation Laboratory (MOSE), University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy. Electronic address: sabrina.pricl@di3.units.it., Catapano CV; Institute of Oncology Research (IOR), Via Vela 6, 6500 Bellinzona, Switzerland; Oncology Institute of Southern Switzerland (IOSI), Via Vela 6, 6500 Bellinzona, Switzerland. Electronic address: carlo.catapano@ior.iosi.ch.
Source: Molecular oncology [Mol Oncol] 2015 Jun; Vol. 9 (6), pp. 1194-206. Date of Electronic Publication: 2015 Mar 05.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 101308230 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-0261 (Electronic) Linking ISSN: 15747891 NLM ISO Abbreviation: Mol Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1878-0261
DOI:10.1016/j.molonc.2015.02.012