The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase.

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Title: The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase.
Authors: Vicuña L; Pharmacology Institute, University of Heidelberg, Heidelberg, Germany., Strochlic DE; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA., Latremoliere A; 1] F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA. [2] Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA., Bali KK; Pharmacology Institute, University of Heidelberg, Heidelberg, Germany., Simonetti M; Pharmacology Institute, University of Heidelberg, Heidelberg, Germany., Husainie D; Pharmacology Institute, University of Heidelberg, Heidelberg, Germany., Prokosch S; Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany., Riva P; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA., Griffin RS; Department of Anesthesiology (Pain Management), Hospital for Special Surgery, New York, New York, USA., Njoo C; Pharmacology Institute, University of Heidelberg, Heidelberg, Germany., Gehrig S; Department of Translational Pulmonology, Translational Lung Research Center Heidelberg, University of Heidelberg, Heidelberg, Germany., Mall MA; Department of Translational Pulmonology, Translational Lung Research Center Heidelberg, University of Heidelberg, Heidelberg, Germany., Arnold B; Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany., Devor M; Institute of Life Sciences and Center for Research on Pain, The Hebrew University of Jerusalem, Jerusalem, Israel., Woolf CJ; 1] F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA. [2] Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA., Liberles SD; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA., Costigan M; 1] F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA. [2] Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA. [3] Department of Anesthesia, Boston Children's Hospital, Boston, Massachusetts, USA., Kuner R; Pharmacology Institute, University of Heidelberg, Heidelberg, Germany.
Source: Nature medicine [Nat Med] 2015 May; Vol. 21 (5), pp. 518-23. Date of Electronic Publication: 2015 Apr 27.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1546-170X
DOI:10.1038/nm.3852