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The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase.

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Title: The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase.
Authors: Vicuña L; Pharmacology Institute, University of Heidelberg, Heidelberg, Germany., Strochlic DE; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA., Latremoliere A; 1] F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA. [2] Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA., Bali KK; Pharmacology Institute, University of Heidelberg, Heidelberg, Germany., Simonetti M; Pharmacology Institute, University of Heidelberg, Heidelberg, Germany., Husainie D; Pharmacology Institute, University of Heidelberg, Heidelberg, Germany., Prokosch S; Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany., Riva P; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA., Griffin RS; Department of Anesthesiology (Pain Management), Hospital for Special Surgery, New York, New York, USA., Njoo C; Pharmacology Institute, University of Heidelberg, Heidelberg, Germany., Gehrig S; Department of Translational Pulmonology, Translational Lung Research Center Heidelberg, University of Heidelberg, Heidelberg, Germany., Mall MA; Department of Translational Pulmonology, Translational Lung Research Center Heidelberg, University of Heidelberg, Heidelberg, Germany., Arnold B; Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany., Devor M; Institute of Life Sciences and Center for Research on Pain, The Hebrew University of Jerusalem, Jerusalem, Israel., Woolf CJ; 1] F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA. [2] Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA., Liberles SD; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA., Costigan M; 1] F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA. [2] Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA. [3] Department of Anesthesia, Boston Children's Hospital, Boston, Massachusetts, USA., Kuner R; Pharmacology Institute, University of Heidelberg, Heidelberg, Germany.
Source: Nature medicine [Nat Med] 2015 May; Vol. 21 (5), pp. 518-23. Date of Electronic Publication: 2015 Apr 27.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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  Data: The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase.
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  Data: <searchLink fieldCode="AU" term="%22Vicuña+L%22">Vicuña L</searchLink>; Pharmacology Institute, University of Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Strochlic+DE%22">Strochlic DE</searchLink>; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Latremoliere+A%22">Latremoliere A</searchLink>; 1] F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA. [2] Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Bali+KK%22">Bali KK</searchLink>; Pharmacology Institute, University of Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Simonetti+M%22">Simonetti M</searchLink>; Pharmacology Institute, University of Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Husainie+D%22">Husainie D</searchLink>; Pharmacology Institute, University of Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Prokosch+S%22">Prokosch S</searchLink>; Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Riva+P%22">Riva P</searchLink>; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Griffin+RS%22">Griffin RS</searchLink>; Department of Anesthesiology (Pain Management), Hospital for Special Surgery, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Njoo+C%22">Njoo C</searchLink>; Pharmacology Institute, University of Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Gehrig+S%22">Gehrig S</searchLink>; Department of Translational Pulmonology, Translational Lung Research Center Heidelberg, University of Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Mall+MA%22">Mall MA</searchLink>; Department of Translational Pulmonology, Translational Lung Research Center Heidelberg, University of Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Arnold+B%22">Arnold B</searchLink>; Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Devor+M%22">Devor M</searchLink>; Institute of Life Sciences and Center for Research on Pain, The Hebrew University of Jerusalem, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Woolf+CJ%22">Woolf CJ</searchLink>; 1] F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA. [2] Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Liberles+SD%22">Liberles SD</searchLink>; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Costigan+M%22">Costigan M</searchLink>; 1] F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA. [2] Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA. [3] Department of Anesthesia, Boston Children's Hospital, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Kuner+R%22">Kuner R</searchLink>; Pharmacology Institute, University of Heidelberg, Heidelberg, Germany.
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