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Design of Pyridopyrazine-1,6-dione γ-Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic Stability.

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Title: Design of Pyridopyrazine-1,6-dione γ-Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic Stability.
Authors: Pettersson M; Pfizer Worldwide Research & Development , 610 Main Street, Cambridge, Massachusetts 02139, United States., Johnson DS; Pfizer Worldwide Research & Development , 610 Main Street, Cambridge, Massachusetts 02139, United States., Humphrey JM; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States., Butler TW; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States., Am Ende CW; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States., Fish BA; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States., Green ME; Pfizer Worldwide Research & Development , 610 Main Street, Cambridge, Massachusetts 02139, United States., Kauffman GW; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States., Mullins PB; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States., O'Donnell CJ; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States., Stepan AF; Pfizer Worldwide Research & Development , 610 Main Street, Cambridge, Massachusetts 02139, United States., Stiff CM; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States., Subramanyam C; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States., Tran TP; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States., Vetelino BC; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States., Yang E; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States., Xie L; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States., Bales KR; Pfizer Worldwide Research & Development , 610 Main Street, Cambridge, Massachusetts 02139, United States., Pustilnik LR; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States., Steyn SJ; Pfizer Worldwide Research & Development , 610 Main Street, Cambridge, Massachusetts 02139, United States., Wood KM; Pfizer Worldwide Research & Development , 610 Main Street, Cambridge, Massachusetts 02139, United States., Verhoest PR; Pfizer Worldwide Research & Development , 610 Main Street, Cambridge, Massachusetts 02139, United States.
Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2015 Apr 03; Vol. 6 (5), pp. 596-601. Date of Electronic Publication: 2015 Apr 03 (Print Publication: 2015).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Pettersson+M%22">Pettersson M</searchLink>; Pfizer Worldwide Research & Development , 610 Main Street, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Johnson+DS%22">Johnson DS</searchLink>; Pfizer Worldwide Research & Development , 610 Main Street, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Humphrey+JM%22">Humphrey JM</searchLink>; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Butler+TW%22">Butler TW</searchLink>; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Am+Ende+CW%22">Am Ende CW</searchLink>; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Fish+BA%22">Fish BA</searchLink>; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Green+ME%22">Green ME</searchLink>; Pfizer Worldwide Research & Development , 610 Main Street, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Kauffman+GW%22">Kauffman GW</searchLink>; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Mullins+PB%22">Mullins PB</searchLink>; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22O'Donnell+CJ%22">O'Donnell CJ</searchLink>; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Stepan+AF%22">Stepan AF</searchLink>; Pfizer Worldwide Research & Development , 610 Main Street, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Stiff+CM%22">Stiff CM</searchLink>; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Subramanyam+C%22">Subramanyam C</searchLink>; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Tran+TP%22">Tran TP</searchLink>; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Vetelino+BC%22">Vetelino BC</searchLink>; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Yang+E%22">Yang E</searchLink>; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Xie+L%22">Xie L</searchLink>; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Bales+KR%22">Bales KR</searchLink>; Pfizer Worldwide Research & Development , 610 Main Street, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Pustilnik+LR%22">Pustilnik LR</searchLink>; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Steyn+SJ%22">Steyn SJ</searchLink>; Pfizer Worldwide Research & Development , 610 Main Street, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Wood+KM%22">Wood KM</searchLink>; Pfizer Worldwide Research & Development , 610 Main Street, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Verhoest+PR%22">Verhoest PR</searchLink>; Pfizer Worldwide Research & Development , 610 Main Street, Cambridge, Massachusetts 02139, United States.
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  Data: <searchLink fieldCode="JN" term="%22101521073%22">ACS medicinal chemistry letters</searchLink> [ACS Med Chem Lett] 2015 Apr 03; Vol. 6 (5), pp. 596-601. <i>Date of Electronic Publication: </i>2015 Apr 03 (<i>Print Publication: </i>2015).
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