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Design of Pyridopyrazine-1,6-dione γ-Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic Stability.

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Bibliographic Details
Title: Design of Pyridopyrazine-1,6-dione γ-Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic Stability.
Authors: Pettersson M; Pfizer Worldwide Research & Development , 610 Main Street, Cambridge, Massachusetts 02139, United States., Johnson DS; Pfizer Worldwide Research & Development , 610 Main Street, Cambridge, Massachusetts 02139, United States., Humphrey JM; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States., Butler TW; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States., Am Ende CW; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States., Fish BA; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States., Green ME; Pfizer Worldwide Research & Development , 610 Main Street, Cambridge, Massachusetts 02139, United States., Kauffman GW; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States., Mullins PB; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States., O'Donnell CJ; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States., Stepan AF; Pfizer Worldwide Research & Development , 610 Main Street, Cambridge, Massachusetts 02139, United States., Stiff CM; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States., Subramanyam C; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States., Tran TP; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States., Vetelino BC; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States., Yang E; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States., Xie L; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States., Bales KR; Pfizer Worldwide Research & Development , 610 Main Street, Cambridge, Massachusetts 02139, United States., Pustilnik LR; Pfizer Worldwide Research & Development , Eastern Point Road, Groton, Connecticut 06340, United States., Steyn SJ; Pfizer Worldwide Research & Development , 610 Main Street, Cambridge, Massachusetts 02139, United States., Wood KM; Pfizer Worldwide Research & Development , 610 Main Street, Cambridge, Massachusetts 02139, United States., Verhoest PR; Pfizer Worldwide Research & Development , 610 Main Street, Cambridge, Massachusetts 02139, United States.
Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2015 Apr 03; Vol. 6 (5), pp. 596-601. Date of Electronic Publication: 2015 Apr 03 (Print Publication: 2015).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1948-5875
DOI:10.1021/acsmedchemlett.5b00070