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MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation.

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Title: MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation.
Authors: Laberge RM; Buck Institute for Research on Aging, Novato, California 94945, USA., Sun Y; 1] Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA [2] Key Lab of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China., Orjalo AV; Buck Institute for Research on Aging, Novato, California 94945, USA., Patil CK; Buck Institute for Research on Aging, Novato, California 94945, USA., Freund A; Buck Institute for Research on Aging, Novato, California 94945, USA., Zhou L; Buck Institute for Research on Aging, Novato, California 94945, USA., Curran SC; Buck Institute for Research on Aging, Novato, California 94945, USA., Davalos AR; Buck Institute for Research on Aging, Novato, California 94945, USA., Wilson-Edell KA; Buck Institute for Research on Aging, Novato, California 94945, USA., Liu S; Buck Institute for Research on Aging, Novato, California 94945, USA., Limbad C; Buck Institute for Research on Aging, Novato, California 94945, USA., Demaria M; Buck Institute for Research on Aging, Novato, California 94945, USA., Li P; Buck Institute for Research on Aging, Novato, California 94945, USA., Hubbard GB; 1] Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA [2] Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA., Ikeno Y; 1] Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA [2] Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA [3] Research Service, San Antonio, Texas 78229, USA [4] GRECC, Audie Murphy VA Hospital (STVHCS), San Antonio, Texas 78229, USA., Javors M; Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA., Desprez PY; 1] Buck Institute for Research on Aging, Novato, California 94945, USA [2] California Pacific Medical Center, Research Institute, San Francisco, California 94107, USA., Benz CC; Buck Institute for Research on Aging, Novato, California 94945, USA., Kapahi P; Buck Institute for Research on Aging, Novato, California 94945, USA., Nelson PS; Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Campisi J; Buck Institute for Research on Aging, Novato, California 94945, USA.
Source: Nature cell biology [Nat Cell Biol] 2015 Aug; Vol. 17 (8), pp. 1049-61. Date of Electronic Publication: 2015 Jul 06.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-4679
DOI:10.1038/ncb3195