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Carbamoyl Triazoles, Known Serine Protease Inhibitors, Are a Potent New Class of Antimalarials.

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Title: Carbamoyl Triazoles, Known Serine Protease Inhibitors, Are a Potent New Class of Antimalarials.
Authors: McConville M; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Spain., Fernández J; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Spain., Angulo-Barturen Í; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Spain., Bahamontes-Rosa N; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Spain., Ballell-Pages L; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Spain., Castañeda P; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Spain., de Cózar C; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Spain., Crespo B; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Spain., Guijarro L; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Spain., Jiménez-Díaz MB; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Spain., Martínez-Martínez MS; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Spain., de Mercado J; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Spain., Santos-Villarejo Á; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Spain., Sanz LM; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Spain., Frigerio M; Department of Chemistry, University of Liverpool , Liverpool L69 7ZD, United Kingdom., Washbourn G; Department of Chemistry, University of Liverpool , Liverpool L69 7ZD, United Kingdom., Ward SA; Liverpool School of Tropical Medicine , Pembroke Place, Liverpool L3 5QA, United Kingdom., Nixon GL; Department of Chemistry, University of Liverpool , Liverpool L69 7ZD, United Kingdom., Biagini GA; Liverpool School of Tropical Medicine , Pembroke Place, Liverpool L3 5QA, United Kingdom., Berry NG; Department of Chemistry, University of Liverpool , Liverpool L69 7ZD, United Kingdom., Blackman MJ; Division of Parasitology, MRC National Institute for Medical Research , Mill Hill, London NW7 1AA, United Kingdom., Calderón F; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Spain., O'Neill PM; Department of Chemistry, University of Liverpool , Liverpool L69 7ZD, United Kingdom.
Source: Journal of medicinal chemistry [J Med Chem] 2015 Aug 27; Vol. 58 (16), pp. 6448-55. Date of Electronic Publication: 2015 Aug 17.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Carbamoyl Triazoles, Known Serine Protease Inhibitors, Are a Potent New Class of Antimalarials.
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  Data: <searchLink fieldCode="AU" term="%22McConville+M%22">McConville M</searchLink>; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Spain.<br /><searchLink fieldCode="AU" term="%22Fernández+J%22">Fernández J</searchLink>; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Spain.<br /><searchLink fieldCode="AU" term="%22Angulo-Barturen+Í%22">Angulo-Barturen Í</searchLink>; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Spain.<br /><searchLink fieldCode="AU" term="%22Bahamontes-Rosa+N%22">Bahamontes-Rosa N</searchLink>; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Spain.<br /><searchLink fieldCode="AU" term="%22Ballell-Pages+L%22">Ballell-Pages L</searchLink>; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Spain.<br /><searchLink fieldCode="AU" term="%22Castañeda+P%22">Castañeda P</searchLink>; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Spain.<br /><searchLink fieldCode="AU" term="%22de+Cózar+C%22">de Cózar C</searchLink>; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Spain.<br /><searchLink fieldCode="AU" term="%22Crespo+B%22">Crespo B</searchLink>; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Spain.<br /><searchLink fieldCode="AU" term="%22Guijarro+L%22">Guijarro L</searchLink>; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Spain.<br /><searchLink fieldCode="AU" term="%22Jiménez-Díaz+MB%22">Jiménez-Díaz MB</searchLink>; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Spain.<br /><searchLink fieldCode="AU" term="%22Martínez-Martínez+MS%22">Martínez-Martínez MS</searchLink>; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Spain.<br /><searchLink fieldCode="AU" term="%22de+Mercado+J%22">de Mercado J</searchLink>; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Spain.<br /><searchLink fieldCode="AU" term="%22Santos-Villarejo+Á%22">Santos-Villarejo Á</searchLink>; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Spain.<br /><searchLink fieldCode="AU" term="%22Sanz+LM%22">Sanz LM</searchLink>; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Spain.<br /><searchLink fieldCode="AU" term="%22Frigerio+M%22">Frigerio M</searchLink>; Department of Chemistry, University of Liverpool , Liverpool L69 7ZD, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Washbourn+G%22">Washbourn G</searchLink>; Department of Chemistry, University of Liverpool , Liverpool L69 7ZD, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Ward+SA%22">Ward SA</searchLink>; Liverpool School of Tropical Medicine , Pembroke Place, Liverpool L3 5QA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Nixon+GL%22">Nixon GL</searchLink>; Department of Chemistry, University of Liverpool , Liverpool L69 7ZD, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Biagini+GA%22">Biagini GA</searchLink>; Liverpool School of Tropical Medicine , Pembroke Place, Liverpool L3 5QA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Berry+NG%22">Berry NG</searchLink>; Department of Chemistry, University of Liverpool , Liverpool L69 7ZD, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Blackman+MJ%22">Blackman MJ</searchLink>; Division of Parasitology, MRC National Institute for Medical Research , Mill Hill, London NW7 1AA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Calderón+F%22">Calderón F</searchLink>; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Spain.<br /><searchLink fieldCode="AU" term="%22O'Neill+PM%22">O'Neill PM</searchLink>; Department of Chemistry, University of Liverpool , Liverpool L69 7ZD, United Kingdom.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2015 Aug 27; Vol. 58 (16), pp. 6448-55. <i>Date of Electronic Publication: </i>2015 Aug 17.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1021/acs.jmedchem.5b00434
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