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A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo.

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Title: A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo.
Authors: Saunders LR; Stemcentrx Inc., South San Francisco, CA 94080, USA., Bankovich AJ; Stemcentrx Inc., South San Francisco, CA 94080, USA., Anderson WC; Stemcentrx Inc., South San Francisco, CA 94080, USA., Aujay MA; Stemcentrx Inc., South San Francisco, CA 94080, USA., Bheddah S; Stemcentrx Inc., South San Francisco, CA 94080, USA., Black K; Stemcentrx Inc., South San Francisco, CA 94080, USA., Desai R; Stemcentrx Inc., South San Francisco, CA 94080, USA., Escarpe PA; Stemcentrx Inc., South San Francisco, CA 94080, USA., Hampl J; Stemcentrx Inc., South San Francisco, CA 94080, USA., Laysang A; Stemcentrx Inc., South San Francisco, CA 94080, USA., Liu D; Stemcentrx Inc., South San Francisco, CA 94080, USA., Lopez-Molina J; Stemcentrx Inc., South San Francisco, CA 94080, USA., Milton M; Stemcentrx Inc., South San Francisco, CA 94080, USA., Park A; Stemcentrx Inc., South San Francisco, CA 94080, USA., Pysz MA; Stemcentrx Inc., South San Francisco, CA 94080, USA., Shao H; Stemcentrx Inc., South San Francisco, CA 94080, USA., Slingerland B; Stemcentrx Inc., South San Francisco, CA 94080, USA., Torgov M; Stemcentrx Inc., South San Francisco, CA 94080, USA., Williams SA; Stemcentrx Inc., South San Francisco, CA 94080, USA., Foord O; Stemcentrx Inc., South San Francisco, CA 94080, USA., Howard P; Spirogen (a member of the AstraZeneca Group), London W2 6BD, UK., Jassem J; Medical University of Gdańsk, Gdańsk 82-300, Poland., Badzio A; Medical University of Gdańsk, Gdańsk 82-300, Poland., Czapiewski P; Medical University of Gdańsk, Gdańsk 82-300, Poland., Harpole DH; Duke University Medical Cancer, Durham, NC 27710, USA., Dowlati A; Case Western Reserve University and University Hospitals Seidman Cancer Center, Cleveland, OH 44106, USA., Massion PP; Thoracic Program, Vanderbilt-Ingram Cancer Center, Tennessee Valley Healthcare Systems, Nashville Campus, Nashville, TN 37232, USA., Travis WD; Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Pietanza MC; Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Weill Cornell Medical College, New York, NY 10065, USA., Poirier JT; Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Weill Cornell Medical College, New York, NY 10065, USA., Rudin CM; Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Stull RA; Stemcentrx Inc., South San Francisco, CA 94080, USA., Dylla SJ; Stemcentrx Inc., South San Francisco, CA 94080, USA. scott.dylla@stemcentrx.com.
Source: Science translational medicine [Sci Transl Med] 2015 Aug 26; Vol. 7 (302), pp. 302ra136.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo.
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  Data: <searchLink fieldCode="AU" term="%22Saunders+LR%22">Saunders LR</searchLink>; Stemcentrx Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Bankovich+AJ%22">Bankovich AJ</searchLink>; Stemcentrx Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Anderson+WC%22">Anderson WC</searchLink>; Stemcentrx Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Aujay+MA%22">Aujay MA</searchLink>; Stemcentrx Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Bheddah+S%22">Bheddah S</searchLink>; Stemcentrx Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Black+K%22">Black K</searchLink>; Stemcentrx Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Desai+R%22">Desai R</searchLink>; Stemcentrx Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Escarpe+PA%22">Escarpe PA</searchLink>; Stemcentrx Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Hampl+J%22">Hampl J</searchLink>; Stemcentrx Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Laysang+A%22">Laysang A</searchLink>; Stemcentrx Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Liu+D%22">Liu D</searchLink>; Stemcentrx Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Lopez-Molina+J%22">Lopez-Molina J</searchLink>; Stemcentrx Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Milton+M%22">Milton M</searchLink>; Stemcentrx Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Park+A%22">Park A</searchLink>; Stemcentrx Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Pysz+MA%22">Pysz MA</searchLink>; Stemcentrx Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Shao+H%22">Shao H</searchLink>; Stemcentrx Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Slingerland+B%22">Slingerland B</searchLink>; Stemcentrx Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Torgov+M%22">Torgov M</searchLink>; Stemcentrx Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Williams+SA%22">Williams SA</searchLink>; Stemcentrx Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Foord+O%22">Foord O</searchLink>; Stemcentrx Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Howard+P%22">Howard P</searchLink>; Spirogen (a member of the AstraZeneca Group), London W2 6BD, UK.<br /><searchLink fieldCode="AU" term="%22Jassem+J%22">Jassem J</searchLink>; Medical University of Gdańsk, Gdańsk 82-300, Poland.<br /><searchLink fieldCode="AU" term="%22Badzio+A%22">Badzio A</searchLink>; Medical University of Gdańsk, Gdańsk 82-300, Poland.<br /><searchLink fieldCode="AU" term="%22Czapiewski+P%22">Czapiewski P</searchLink>; Medical University of Gdańsk, Gdańsk 82-300, Poland.<br /><searchLink fieldCode="AU" term="%22Harpole+DH%22">Harpole DH</searchLink>; Duke University Medical Cancer, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Dowlati+A%22">Dowlati A</searchLink>; Case Western Reserve University and University Hospitals Seidman Cancer Center, Cleveland, OH 44106, USA.<br /><searchLink fieldCode="AU" term="%22Massion+PP%22">Massion PP</searchLink>; Thoracic Program, Vanderbilt-Ingram Cancer Center, Tennessee Valley Healthcare Systems, Nashville Campus, Nashville, TN 37232, USA.<br /><searchLink fieldCode="AU" term="%22Travis+WD%22">Travis WD</searchLink>; Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Pietanza+MC%22">Pietanza MC</searchLink>; Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Weill Cornell Medical College, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Poirier+JT%22">Poirier JT</searchLink>; Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Weill Cornell Medical College, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Rudin+CM%22">Rudin CM</searchLink>; Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Stull+RA%22">Stull RA</searchLink>; Stemcentrx Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Dylla+SJ%22">Dylla SJ</searchLink>; Stemcentrx Inc., South San Francisco, CA 94080, USA. scott.dylla@stemcentrx.com.
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