Non-β-blocking R-carvedilol enantiomer suppresses Ca2+ waves and stress-induced ventricular tachyarrhythmia without lowering heart rate or blood pressure.

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Bibliographic Details
Title: Non-β-blocking R-carvedilol enantiomer suppresses Ca2+ waves and stress-induced ventricular tachyarrhythmia without lowering heart rate or blood pressure.
Authors: Zhang J; Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, IL 60612 U.S.A., Zhou Q; Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, IL 60612 U.S.A., Smith CD; Department of Chemistry, University of Calgary, Calgary, Alberta, Canada, T2N 1N4., Chen H; Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, IL 60612 U.S.A., Tan Z; Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, IL 60612 U.S.A., Chen B; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, U.S.A., Nani A; Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, IL 60612 U.S.A., Wu G; Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, IL 60612 U.S.A., Song LS; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, U.S.A., Fill M; Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, IL 60612 U.S.A. michael_fill@rush.edu tgback@ucalgary.ca swchen@ucalgary.ca., Back TG; Department of Chemistry, University of Calgary, Calgary, Alberta, Canada, T2N 1N4 michael_fill@rush.edu tgback@ucalgary.ca swchen@ucalgary.ca., Chen SR; Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, IL 60612 U.S.A. The Libin Cardiovascular Institute of Alberta, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada, T2N 4N1 michael_fill@rush.edu tgback@ucalgary.ca swchen@ucalgary.ca.
Source: The Biochemical journal [Biochem J] 2015 Sep 01; Vol. 470 (2), pp. 233-42. Date of Electronic Publication: 2015 Jul 08.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1470-8728
DOI:10.1042/BJ20150548