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Chaperoning epigenetics: FKBP51 decreases the activity of DNMT1 and mediates epigenetic effects of the antidepressant paroxetine.

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Title: Chaperoning epigenetics: FKBP51 decreases the activity of DNMT1 and mediates epigenetic effects of the antidepressant paroxetine.
Authors: Gassen NC; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany. ncgassen@psych.mpg.de theorein@psych.mpg.de., Fries GR; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany. Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center, Houston, TX 77054, USA., Zannas AS; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA., Hartmann J; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, 80804 Munich, Germany., Zschocke J; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany., Hafner K; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany., Carrillo-Roa T; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany., Steinbacher J; Department of Organic Chemistry, Faculty of Chemistry and Pharmacy, Ludwig Maximilians University, 81377 Munich, Germany., Preißinger SN; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany., Hoeijmakers L; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, 80804 Munich, Germany., Knop M; Department of Clinical Research, Max Planck Institute of Psychiatry, 80804 Munich, Germany., Weber F; Department of Clinical Research, Max Planck Institute of Psychiatry, 80804 Munich, Germany., Kloiber S; Department of Clinical Research, Max Planck Institute of Psychiatry, 80804 Munich, Germany., Lucae S; Department of Clinical Research, Max Planck Institute of Psychiatry, 80804 Munich, Germany., Chrousos GP; First Department of Pediatrics, University of Athens Medical School, Athens 11527, Greece., Carell T; Department of Organic Chemistry, Faculty of Chemistry and Pharmacy, Ludwig Maximilians University, 81377 Munich, Germany., Ising M; Department of Clinical Research, Max Planck Institute of Psychiatry, 80804 Munich, Germany., Binder EB; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany. Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30329, USA., Schmidt MV; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, 80804 Munich, Germany., Rüegg J; Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, 171 76 Stockholm, Sweden and Swedish Toxicology Science Research Center, Swetox, 151 36 Södertälje, Sweden., Rein T; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany. ncgassen@psych.mpg.de theorein@psych.mpg.de.
Source: Science signaling [Sci Signal] 2015 Nov 24; Vol. 8 (404), pp. ra119. Date of Electronic Publication: 2015 Nov 24.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE
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  Data: Chaperoning epigenetics: FKBP51 decreases the activity of DNMT1 and mediates epigenetic effects of the antidepressant paroxetine.
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  Data: <searchLink fieldCode="AU" term="%22Gassen+NC%22">Gassen NC</searchLink>; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany. ncgassen@psych.mpg.de theorein@psych.mpg.de.<br /><searchLink fieldCode="AU" term="%22Fries+GR%22">Fries GR</searchLink>; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany. Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center, Houston, TX 77054, USA.<br /><searchLink fieldCode="AU" term="%22Zannas+AS%22">Zannas AS</searchLink>; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Hartmann+J%22">Hartmann J</searchLink>; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, 80804 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Zschocke+J%22">Zschocke J</searchLink>; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Hafner+K%22">Hafner K</searchLink>; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Carrillo-Roa+T%22">Carrillo-Roa T</searchLink>; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Steinbacher+J%22">Steinbacher J</searchLink>; Department of Organic Chemistry, Faculty of Chemistry and Pharmacy, Ludwig Maximilians University, 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Preißinger+SN%22">Preißinger SN</searchLink>; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Hoeijmakers+L%22">Hoeijmakers L</searchLink>; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, 80804 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Knop+M%22">Knop M</searchLink>; Department of Clinical Research, Max Planck Institute of Psychiatry, 80804 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Weber+F%22">Weber F</searchLink>; Department of Clinical Research, Max Planck Institute of Psychiatry, 80804 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Kloiber+S%22">Kloiber S</searchLink>; Department of Clinical Research, Max Planck Institute of Psychiatry, 80804 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Lucae+S%22">Lucae S</searchLink>; Department of Clinical Research, Max Planck Institute of Psychiatry, 80804 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Chrousos+GP%22">Chrousos GP</searchLink>; First Department of Pediatrics, University of Athens Medical School, Athens 11527, Greece.<br /><searchLink fieldCode="AU" term="%22Carell+T%22">Carell T</searchLink>; Department of Organic Chemistry, Faculty of Chemistry and Pharmacy, Ludwig Maximilians University, 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Ising+M%22">Ising M</searchLink>; Department of Clinical Research, Max Planck Institute of Psychiatry, 80804 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Binder+EB%22">Binder EB</searchLink>; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany. Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30329, USA.<br /><searchLink fieldCode="AU" term="%22Schmidt+MV%22">Schmidt MV</searchLink>; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, 80804 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Rüegg+J%22">Rüegg J</searchLink>; Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, 171 76 Stockholm, Sweden and Swedish Toxicology Science Research Center, Swetox, 151 36 Södertälje, Sweden.<br /><searchLink fieldCode="AU" term="%22Rein+T%22">Rein T</searchLink>; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany. ncgassen@psych.mpg.de theorein@psych.mpg.de.
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