Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators.

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Title:	Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators.
Authors:	Rajamohan F; Department of World Wide Medicinal Chemistry, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, U.S.A., Reyes AR; CVMED Research unit, Pfizer Global Research and Development, 620 Memorial Drive, Cambridge, MA 02139, U.S.A., Frisbie RK; The Department of Pharmacokinetics Dynamics and Metabolism, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, U.S.A., Hoth LR; Department of World Wide Medicinal Chemistry, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, U.S.A., Sahasrabudhe P; Department of World Wide Medicinal Chemistry, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, U.S.A., Magyar R; Department of World Wide Medicinal Chemistry, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, U.S.A., Landro JA; CVMED Research unit, Pfizer Global Research and Development, 620 Memorial Drive, Cambridge, MA 02139, U.S.A., Withka JM; Department of World Wide Medicinal Chemistry, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, U.S.A., Caspers NL; Department of World Wide Medicinal Chemistry, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, U.S.A., Calabrese MF; Department of World Wide Medicinal Chemistry, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, U.S.A., Ward J; CVMED Research unit, Pfizer Global Research and Development, 620 Memorial Drive, Cambridge, MA 02139, U.S.A., Kurumbail RG; Department of World Wide Medicinal Chemistry, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, U.S.A. ravi.g.kurumbail@pfizer.com.
Source:	The Biochemical journal [Biochem J] 2016 Mar 01; Vol. 473 (5), pp. 581-92. Date of Electronic Publication: 2015 Dec 03.
Publication Type:	Journal Article; Research Support, Non-U.S. Gov't
Journal Info:	Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE
Database:	MEDLINE Ultimate

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ISSN:	1470-8728
DOI:	10.1042/BJ20151051