Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators.
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| Title: | Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators. |
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| Authors: | Rajamohan F; Department of World Wide Medicinal Chemistry, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, U.S.A., Reyes AR; CVMED Research unit, Pfizer Global Research and Development, 620 Memorial Drive, Cambridge, MA 02139, U.S.A., Frisbie RK; The Department of Pharmacokinetics Dynamics and Metabolism, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, U.S.A., Hoth LR; Department of World Wide Medicinal Chemistry, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, U.S.A., Sahasrabudhe P; Department of World Wide Medicinal Chemistry, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, U.S.A., Magyar R; Department of World Wide Medicinal Chemistry, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, U.S.A., Landro JA; CVMED Research unit, Pfizer Global Research and Development, 620 Memorial Drive, Cambridge, MA 02139, U.S.A., Withka JM; Department of World Wide Medicinal Chemistry, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, U.S.A., Caspers NL; Department of World Wide Medicinal Chemistry, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, U.S.A., Calabrese MF; Department of World Wide Medicinal Chemistry, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, U.S.A., Ward J; CVMED Research unit, Pfizer Global Research and Development, 620 Memorial Drive, Cambridge, MA 02139, U.S.A., Kurumbail RG; Department of World Wide Medicinal Chemistry, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, U.S.A. ravi.g.kurumbail@pfizer.com. |
| Source: | The Biochemical journal [Biochem J] 2016 Mar 01; Vol. 473 (5), pp. 581-92. Date of Electronic Publication: 2015 Dec 03. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 26635351 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Rajamohan+F%22">Rajamohan F</searchLink>; Department of World Wide Medicinal Chemistry, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, U.S.A.<br /><searchLink fieldCode="AU" term="%22Reyes+AR%22">Reyes AR</searchLink>; CVMED Research unit, Pfizer Global Research and Development, 620 Memorial Drive, Cambridge, MA 02139, U.S.A.<br /><searchLink fieldCode="AU" term="%22Frisbie+RK%22">Frisbie RK</searchLink>; The Department of Pharmacokinetics Dynamics and Metabolism, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, U.S.A.<br /><searchLink fieldCode="AU" term="%22Hoth+LR%22">Hoth LR</searchLink>; Department of World Wide Medicinal Chemistry, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, U.S.A.<br /><searchLink fieldCode="AU" term="%22Sahasrabudhe+P%22">Sahasrabudhe P</searchLink>; Department of World Wide Medicinal Chemistry, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, U.S.A.<br /><searchLink fieldCode="AU" term="%22Magyar+R%22">Magyar R</searchLink>; Department of World Wide Medicinal Chemistry, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, U.S.A.<br /><searchLink fieldCode="AU" term="%22Landro+JA%22">Landro JA</searchLink>; CVMED Research unit, Pfizer Global Research and Development, 620 Memorial Drive, Cambridge, MA 02139, U.S.A.<br /><searchLink fieldCode="AU" term="%22Withka+JM%22">Withka JM</searchLink>; Department of World Wide Medicinal Chemistry, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, U.S.A.<br /><searchLink fieldCode="AU" term="%22Caspers+NL%22">Caspers NL</searchLink>; Department of World Wide Medicinal Chemistry, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, U.S.A.<br /><searchLink fieldCode="AU" term="%22Calabrese+MF%22">Calabrese MF</searchLink>; Department of World Wide Medicinal Chemistry, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, U.S.A.<br /><searchLink fieldCode="AU" term="%22Ward+J%22">Ward J</searchLink>; CVMED Research unit, Pfizer Global Research and Development, 620 Memorial Drive, Cambridge, MA 02139, U.S.A.<br /><searchLink fieldCode="AU" term="%22Kurumbail+RG%22">Kurumbail RG</searchLink>; Department of World Wide Medicinal Chemistry, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, U.S.A. ravi.g.kurumbail@pfizer.com. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%222984726R%22">The Biochemical journal</searchLink> [Biochem J] 2016 Mar 01; Vol. 473 (5), pp. 581-92. <i>Date of Electronic Publication: </i>2015 Dec 03. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Published+by+Portland+Press+on+behalf+of+the+Biochemical+Society%22">Published by Portland Press on behalf of the Biochemical Society </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>2984726R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1470-8728 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202646021%22">02646021 </searchLink><i>NLM ISO Abbreviation: </i>Biochem J <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=26635351 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1042/BJ20151051 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 581 Titles: – TitleFull: Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Rajamohan F – PersonEntity: Name: NameFull: Reyes AR – PersonEntity: Name: NameFull: Frisbie RK – PersonEntity: Name: NameFull: Hoth LR – PersonEntity: Name: NameFull: Sahasrabudhe P – PersonEntity: Name: NameFull: Magyar R – PersonEntity: Name: NameFull: Landro JA – PersonEntity: Name: NameFull: Withka JM – PersonEntity: Name: NameFull: Caspers NL – PersonEntity: Name: NameFull: Calabrese MF – PersonEntity: Name: NameFull: Ward J – PersonEntity: Name: NameFull: Kurumbail RG IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: 2016 Mar 01 Type: published Y: 2016 Identifiers: – Type: issn-electronic Value: 1470-8728 Numbering: – Type: volume Value: 473 – Type: issue Value: 5 Titles: – TitleFull: The Biochemical journal Type: main |
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