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Safety and Immunogenicity of Novel Adenovirus Type 26- and Modified Vaccinia Ankara-Vectored Ebola Vaccines: A Randomized Clinical Trial.

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Title: Safety and Immunogenicity of Novel Adenovirus Type 26- and Modified Vaccinia Ankara-Vectored Ebola Vaccines: A Randomized Clinical Trial.
Authors: Milligan ID; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom., Gibani MM; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom., Sewell R; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom., Clutterbuck EA; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom., Campbell D; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom., Plested E; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom., Nuthall E; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom., Voysey M; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom2Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom., Silva-Reyes L; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom., McElrath MJ; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington., De Rosa SC; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington., Frahm N; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington., Cohen KW; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington., Shukarev G; Janssen, Pharmaceutical Companies of Johnson & Johnson, Leiden, the Netherlands., Orzabal N; Janssen, Pharmaceutical Companies of Johnson & Johnson, Leiden, the Netherlands., van Duijnhoven W; Janssen, Pharmaceutical Companies of Johnson & Johnson, Leiden, the Netherlands., Truyers C; Janssen, Pharmaceutical Companies of Johnson & Johnson, Leiden, the Netherlands., Bachmayer N; Janssen, Pharmaceutical Companies of Johnson & Johnson, Leiden, the Netherlands., Splinter D; Janssen, Pharmaceutical Companies of Johnson & Johnson, Leiden, the Netherlands., Samy N; Bavarian Nordic, Martinsried, Germany., Pau MG; Janssen, Pharmaceutical Companies of Johnson & Johnson, Leiden, the Netherlands., Schuitemaker H; Janssen, Pharmaceutical Companies of Johnson & Johnson, Leiden, the Netherlands., Luhn K; Janssen, Pharmaceutical Companies of Johnson & Johnson, Leiden, the Netherlands., Callendret B; Janssen, Pharmaceutical Companies of Johnson & Johnson, Leiden, the Netherlands., Van Hoof J; Janssen, Pharmaceutical Companies of Johnson & Johnson, Leiden, the Netherlands., Douoguih M; Janssen, Pharmaceutical Companies of Johnson & Johnson, Leiden, the Netherlands., Ewer K; Jenner Institute, Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Oxford, United Kingdom7National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, Oxford, United Kingdom., Angus B; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Pollard AJ; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom7National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, Oxford, United Kingdom., Snape MD; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom7National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, Oxford, United Kingdom.
Source: JAMA [JAMA] 2016 Apr 19; Vol. 315 (15), pp. 1610-23.
Publication Type: Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE
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Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Voysey+M%22">Voysey M</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom2Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Silva-Reyes+L%22">Silva-Reyes L</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22McElrath+MJ%22">McElrath MJ</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.<br /><searchLink fieldCode="AU" term="%22De+Rosa+SC%22">De Rosa SC</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.<br /><searchLink fieldCode="AU" term="%22Frahm+N%22">Frahm N</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.<br /><searchLink fieldCode="AU" term="%22Cohen+KW%22">Cohen KW</searchLink>; 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