5'-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates.
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| Title: | 5'-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates. |
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| Authors: | Parmar R; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA., Willoughby JL; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA., Liu J; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA., Foster DJ; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA., Brigham B; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA., Theile CS; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA., Charisse K; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA., Akinc A; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA., Guidry E; Merck and Co., Inc, 770 Sumneytown Pike, West Point, PA, 19486, USA., Pei Y; Merck and Co., Inc, 770 Sumneytown Pike, West Point, PA, 19486, USA., Strapps W; Merck and Co., Inc, 770 Sumneytown Pike, West Point, PA, 19486, USA., Cancilla M; Merck and Co., Inc, 770 Sumneytown Pike, West Point, PA, 19486, USA., Stanton MG; Merck and Co., Inc, 770 Sumneytown Pike, West Point, PA, 19486, USA., Rajeev KG; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA., Sepp-Lorenzino L; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA., Manoharan M; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA., Meyers R; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA., Maier MA; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA., Jadhav V; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA. vjadhav@alnylam.com. |
| Source: | Chembiochem : a European journal of chemical biology [Chembiochem] 2016 Jun 02; Vol. 17 (11), pp. 985-9. Date of Electronic Publication: 2016 Apr 28. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100937360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-7633 (Electronic) Linking ISSN: 14394227 NLM ISO Abbreviation: Chembiochem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1439-7633 |
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| DOI: | 10.1002/cbic.201600130 |
