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5'-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates.

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Title: 5'-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates.
Authors: Parmar R; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA., Willoughby JL; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA., Liu J; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA., Foster DJ; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA., Brigham B; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA., Theile CS; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA., Charisse K; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA., Akinc A; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA., Guidry E; Merck and Co., Inc, 770 Sumneytown Pike, West Point, PA, 19486, USA., Pei Y; Merck and Co., Inc, 770 Sumneytown Pike, West Point, PA, 19486, USA., Strapps W; Merck and Co., Inc, 770 Sumneytown Pike, West Point, PA, 19486, USA., Cancilla M; Merck and Co., Inc, 770 Sumneytown Pike, West Point, PA, 19486, USA., Stanton MG; Merck and Co., Inc, 770 Sumneytown Pike, West Point, PA, 19486, USA., Rajeev KG; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA., Sepp-Lorenzino L; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA., Manoharan M; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA., Meyers R; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA., Maier MA; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA., Jadhav V; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA. vjadhav@alnylam.com.
Source: Chembiochem : a European journal of chemical biology [Chembiochem] 2016 Jun 02; Vol. 17 (11), pp. 985-9. Date of Electronic Publication: 2016 Apr 28.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100937360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-7633 (Electronic) Linking ISSN: 14394227 NLM ISO Abbreviation: Chembiochem Subsets: MEDLINE
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  Data: 5'-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates.
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  Data: <searchLink fieldCode="AU" term="%22Parmar+R%22">Parmar R</searchLink>; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.<br /><searchLink fieldCode="AU" term="%22Willoughby+JL%22">Willoughby JL</searchLink>; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.<br /><searchLink fieldCode="AU" term="%22Foster+DJ%22">Foster DJ</searchLink>; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.<br /><searchLink fieldCode="AU" term="%22Brigham+B%22">Brigham B</searchLink>; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.<br /><searchLink fieldCode="AU" term="%22Theile+CS%22">Theile CS</searchLink>; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.<br /><searchLink fieldCode="AU" term="%22Charisse+K%22">Charisse K</searchLink>; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.<br /><searchLink fieldCode="AU" term="%22Akinc+A%22">Akinc A</searchLink>; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.<br /><searchLink fieldCode="AU" term="%22Guidry+E%22">Guidry E</searchLink>; Merck and Co., Inc, 770 Sumneytown Pike, West Point, PA, 19486, USA.<br /><searchLink fieldCode="AU" term="%22Pei+Y%22">Pei Y</searchLink>; Merck and Co., Inc, 770 Sumneytown Pike, West Point, PA, 19486, USA.<br /><searchLink fieldCode="AU" term="%22Strapps+W%22">Strapps W</searchLink>; Merck and Co., Inc, 770 Sumneytown Pike, West Point, PA, 19486, USA.<br /><searchLink fieldCode="AU" term="%22Cancilla+M%22">Cancilla M</searchLink>; Merck and Co., Inc, 770 Sumneytown Pike, West Point, PA, 19486, USA.<br /><searchLink fieldCode="AU" term="%22Stanton+MG%22">Stanton MG</searchLink>; Merck and Co., Inc, 770 Sumneytown Pike, West Point, PA, 19486, USA.<br /><searchLink fieldCode="AU" term="%22Rajeev+KG%22">Rajeev KG</searchLink>; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.<br /><searchLink fieldCode="AU" term="%22Sepp-Lorenzino+L%22">Sepp-Lorenzino L</searchLink>; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.<br /><searchLink fieldCode="AU" term="%22Manoharan+M%22">Manoharan M</searchLink>; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.<br /><searchLink fieldCode="AU" term="%22Meyers+R%22">Meyers R</searchLink>; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.<br /><searchLink fieldCode="AU" term="%22Maier+MA%22">Maier MA</searchLink>; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.<br /><searchLink fieldCode="AU" term="%22Jadhav+V%22">Jadhav V</searchLink>; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA. vjadhav@alnylam.com.
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  Data: <searchLink fieldCode="JN" term="%22100937360%22">Chembiochem : a European journal of chemical biology</searchLink> [Chembiochem] 2016 Jun 02; Vol. 17 (11), pp. 985-9. <i>Date of Electronic Publication: </i>2016 Apr 28.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley-VCH+Verlag%22">Wiley-VCH Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>100937360 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1439-7633 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214394227%22">14394227 </searchLink><i>NLM ISO Abbreviation: </i>Chembiochem <i>Subsets: </i>MEDLINE
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      – TitleFull: 5'-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates.
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              Text: 2016 Jun 02
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