A Single Amino Acid Difference between Mouse and Human 5-Lipoxygenase Activating Protein (FLAP) Explains the Speciation and Differential Pharmacology of Novel FLAP Inhibitors.
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| Title: | A Single Amino Acid Difference between Mouse and Human 5-Lipoxygenase Activating Protein (FLAP) Explains the Speciation and Differential Pharmacology of Novel FLAP Inhibitors. |
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| Authors: | Blevitt JM; Discovery Sciences, Janssen Research and Development, San Diego, California 92121., Hack MD; Discovery Sciences, Janssen Research and Development, San Diego, California 92121., Herman K; Discovery Sciences, Janssen Research and Development, San Diego, California 92121., Chang L; From the Departments of Immunology and., Keith JM; From the Departments of Immunology and., Mirzadegan T; Discovery Sciences, Janssen Research and Development, San Diego, California 92121., Rao NL; From the Departments of Immunology and., Lebsack AD; From the Departments of Immunology and., Milla ME; Discovery Sciences, Janssen Research and Development, San Diego, California 92121. Electronic address: mmilla@adaptivebiotech.com. |
| Source: | The Journal of biological chemistry [J Biol Chem] 2016 Jun 10; Vol. 291 (24), pp. 12724-12731. Date of Electronic Publication: 2016 Apr 16. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| ISSN: | 1083-351X |
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| DOI: | 10.1074/jbc.M116.725325 |
