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Understanding How the Stability of the Thiol-Maleimide Linkage Impacts the Pharmacokinetics of Lysine-Linked Antibody-Maytansinoid Conjugates.

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Title: Understanding How the Stability of the Thiol-Maleimide Linkage Impacts the Pharmacokinetics of Lysine-Linked Antibody-Maytansinoid Conjugates.
Authors: Ponte JF; ImmunoGen, Inc., 830 Winter Street, Waltham, Massachusetts 02451-1477, United States., Sun X; ImmunoGen, Inc., 830 Winter Street, Waltham, Massachusetts 02451-1477, United States., Yoder NC; ImmunoGen, Inc., 830 Winter Street, Waltham, Massachusetts 02451-1477, United States., Fishkin N; ImmunoGen, Inc., 830 Winter Street, Waltham, Massachusetts 02451-1477, United States., Laleau R; ImmunoGen, Inc., 830 Winter Street, Waltham, Massachusetts 02451-1477, United States., Coccia J; ImmunoGen, Inc., 830 Winter Street, Waltham, Massachusetts 02451-1477, United States., Lanieri L; ImmunoGen, Inc., 830 Winter Street, Waltham, Massachusetts 02451-1477, United States., Bogalhas M; ImmunoGen, Inc., 830 Winter Street, Waltham, Massachusetts 02451-1477, United States., Wang L; ImmunoGen, Inc., 830 Winter Street, Waltham, Massachusetts 02451-1477, United States., Wilhelm S; ImmunoGen, Inc., 830 Winter Street, Waltham, Massachusetts 02451-1477, United States., Widdison W; ImmunoGen, Inc., 830 Winter Street, Waltham, Massachusetts 02451-1477, United States., Pinkas J; ImmunoGen, Inc., 830 Winter Street, Waltham, Massachusetts 02451-1477, United States., Keating TA; ImmunoGen, Inc., 830 Winter Street, Waltham, Massachusetts 02451-1477, United States., Chari R; ImmunoGen, Inc., 830 Winter Street, Waltham, Massachusetts 02451-1477, United States., Erickson HK; ImmunoGen, Inc., 830 Winter Street, Waltham, Massachusetts 02451-1477, United States., Lambert JM; ImmunoGen, Inc., 830 Winter Street, Waltham, Massachusetts 02451-1477, United States.
Source: Bioconjugate chemistry [Bioconjug Chem] 2016 Jul 20; Vol. 27 (7), pp. 1588-98. Date of Electronic Publication: 2016 Jun 20.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9010319 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4812 (Electronic) Linking ISSN: 10431802 NLM ISO Abbreviation: Bioconjug Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Understanding How the Stability of the Thiol-Maleimide Linkage Impacts the Pharmacokinetics of Lysine-Linked Antibody-Maytansinoid Conjugates.
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