Pharmacological and Genetic Manipulation of p53 in Brown Fat at Adult But Not Embryonic Stages Regulates Thermogenesis and Body Weight in Male Mice.
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| Title: | Pharmacological and Genetic Manipulation of p53 in Brown Fat at Adult But Not Embryonic Stages Regulates Thermogenesis and Body Weight in Male Mice. |
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| Authors: | Al-Massadi O; Department of Physiology (O.A.-M., B.P., M.J.G.-R., M.G.-L., E.D.R., M.Q., A.S., C.V.A., M.L., C.D., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (O.A.-M., B.P., M.J.G.-R., M.Q., M.L., C.D., R.N.), Santiago de Compostela 15706, Spain; Department of Adipocyte Development and Nutrition (D.K., M.K., T.J.S.), German Institute of Human Nutrition Potsdam-Rehbrücke, 14558 Nuthetal, Germany; and German Center for Diabetes Research (T.J.S.), München-Neuherberg 85764, Germany., Porteiro B; Department of Physiology (O.A.-M., B.P., M.J.G.-R., M.G.-L., E.D.R., M.Q., A.S., C.V.A., M.L., C.D., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (O.A.-M., B.P., M.J.G.-R., M.Q., M.L., C.D., R.N.), Santiago de Compostela 15706, Spain; Department of Adipocyte Development and Nutrition (D.K., M.K., T.J.S.), German Institute of Human Nutrition Potsdam-Rehbrücke, 14558 Nuthetal, Germany; and German Center for Diabetes Research (T.J.S.), München-Neuherberg 85764, Germany., Kuhlow D; Department of Physiology (O.A.-M., B.P., M.J.G.-R., M.G.-L., E.D.R., M.Q., A.S., C.V.A., M.L., C.D., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (O.A.-M., B.P., M.J.G.-R., M.Q., M.L., C.D., R.N.), Santiago de Compostela 15706, Spain; Department of Adipocyte Development and Nutrition (D.K., M.K., T.J.S.), German Institute of Human Nutrition Potsdam-Rehbrücke, 14558 Nuthetal, Germany; and German Center for Diabetes Research (T.J.S.), München-Neuherberg 85764, Germany., Köhler M; Department of Physiology (O.A.-M., B.P., M.J.G.-R., M.G.-L., E.D.R., M.Q., A.S., C.V.A., M.L., C.D., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (O.A.-M., B.P., M.J.G.-R., M.Q., M.L., C.D., R.N.), Santiago de Compostela 15706, Spain; Department of Adipocyte Development and Nutrition (D.K., M.K., T.J.S.), German Institute of Human Nutrition Potsdam-Rehbrücke, 14558 Nuthetal, Germany; and German Center for Diabetes Research (T.J.S.), München-Neuherberg 85764, Germany., Gonzalez-Rellan MJ; Department of Physiology (O.A.-M., B.P., M.J.G.-R., M.G.-L., E.D.R., M.Q., A.S., C.V.A., M.L., C.D., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (O.A.-M., B.P., M.J.G.-R., M.Q., M.L., C.D., R.N.), Santiago de Compostela 15706, Spain; Department of Adipocyte Development and Nutrition (D.K., M.K., T.J.S.), German Institute of Human Nutrition Potsdam-Rehbrücke, 14558 Nuthetal, Germany; and German Center for Diabetes Research (T.J.S.), München-Neuherberg 85764, Germany., Garcia-Lavandeira M; Department of Physiology (O.A.-M., B.P., M.J.G.-R., M.G.-L., E.D.R., M.Q., A.S., C.V.A., M.L., C.D., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (O.A.-M., B.P., M.J.G.-R., M.Q., M.L., C.D., R.N.), Santiago de Compostela 15706, Spain; Department of Adipocyte Development and Nutrition (D.K., M.K., T.J.S.), German Institute of Human Nutrition Potsdam-Rehbrücke, 14558 Nuthetal, Germany; and German Center for Diabetes Research (T.J.S.), München-Neuherberg 85764, Germany., Díaz-Rodríguez E; Department of Physiology (O.A.-M., B.P., M.J.G.-R., M.G.-L., E.D.R., M.Q., A.S., C.V.A., M.L., C.D., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (O.A.-M., B.P., M.J.G.-R., M.Q., M.L., C.D., R.N.), Santiago de Compostela 15706, Spain; Department of Adipocyte Development and Nutrition (D.K., M.K., T.J.S.), German Institute of Human Nutrition Potsdam-Rehbrücke, 14558 Nuthetal, Germany; and German Center for Diabetes Research (T.J.S.), München-Neuherberg 85764, Germany., Quiñones M; Department of Physiology (O.A.-M., B.P., M.J.G.-R., M.G.-L., E.D.R., M.Q., A.S., C.V.A., M.L., C.D., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (O.A.-M., B.P., M.J.G.-R., M.Q., M.L., C.D., R.N.), Santiago de Compostela 15706, Spain; Department of Adipocyte Development and Nutrition (D.K., M.K., T.J.S.), German Institute of Human Nutrition Potsdam-Rehbrücke, 14558 Nuthetal, Germany; and German Center for Diabetes Research (T.J.S.), München-Neuherberg 85764, Germany., Senra A; Department of Physiology (O.A.-M., B.P., M.J.G.-R., M.G.-L., E.D.R., M.Q., A.S., C.V.A., M.L., C.D., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (O.A.-M., B.P., M.J.G.-R., M.Q., M.L., C.D., R.N.), Santiago de Compostela 15706, Spain; Department of Adipocyte Development and Nutrition (D.K., M.K., T.J.S.), German Institute of Human Nutrition Potsdam-Rehbrücke, 14558 Nuthetal, Germany; and German Center for Diabetes Research (T.J.S.), München-Neuherberg 85764, Germany., Alvarez CV; Department of Physiology (O.A.-M., B.P., M.J.G.-R., M.G.-L., E.D.R., M.Q., A.S., C.V.A., M.L., C.D., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (O.A.-M., B.P., M.J.G.-R., M.Q., M.L., C.D., R.N.), Santiago de Compostela 15706, Spain; Department of Adipocyte Development and Nutrition (D.K., M.K., T.J.S.), German Institute of Human Nutrition Potsdam-Rehbrücke, 14558 Nuthetal, Germany; and German Center for Diabetes Research (T.J.S.), München-Neuherberg 85764, Germany., López M; Department of Physiology (O.A.-M., B.P., M.J.G.-R., M.G.-L., E.D.R., M.Q., A.S., C.V.A., M.L., C.D., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (O.A.-M., B.P., M.J.G.-R., M.Q., M.L., C.D., R.N.), Santiago de Compostela 15706, Spain; Department of Adipocyte Development and Nutrition (D.K., M.K., T.J.S.), German Institute of Human Nutrition Potsdam-Rehbrücke, 14558 Nuthetal, Germany; and German Center for Diabetes Research (T.J.S.), München-Neuherberg 85764, Germany., Diéguez C; Department of Physiology (O.A.-M., B.P., M.J.G.-R., M.G.-L., E.D.R., M.Q., A.S., C.V.A., M.L., C.D., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (O.A.-M., B.P., M.J.G.-R., M.Q., M.L., C.D., R.N.), Santiago de Compostela 15706, Spain; Department of Adipocyte Development and Nutrition (D.K., M.K., T.J.S.), German Institute of Human Nutrition Potsdam-Rehbrücke, 14558 Nuthetal, Germany; and German Center for Diabetes Research (T.J.S.), München-Neuherberg 85764, Germany., Schulz TJ; Department of Physiology (O.A.-M., B.P., M.J.G.-R., M.G.-L., E.D.R., M.Q., A.S., C.V.A., M.L., C.D., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (O.A.-M., B.P., M.J.G.-R., M.Q., M.L., C.D., R.N.), Santiago de Compostela 15706, Spain; Department of Adipocyte Development and Nutrition (D.K., M.K., T.J.S.), German Institute of Human Nutrition Potsdam-Rehbrücke, 14558 Nuthetal, Germany; and German Center for Diabetes Research (T.J.S.), München-Neuherberg 85764, Germany., Nogueiras R; Department of Physiology (O.A.-M., B.P., M.J.G.-R., M.G.-L., E.D.R., M.Q., A.S., C.V.A., M.L., C.D., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (O.A.-M., B.P., M.J.G.-R., M.Q., M.L., C.D., R.N.), Santiago de Compostela 15706, Spain; Department of Adipocyte Development and Nutrition (D.K., M.K., T.J.S.), German Institute of Human Nutrition Potsdam-Rehbrücke, 14558 Nuthetal, Germany; and German Center for Diabetes Research (T.J.S.), München-Neuherberg 85764, Germany. |
| Source: | Endocrinology [Endocrinology] 2016 Jul; Vol. 157 (7), pp. 2735-49. Date of Electronic Publication: 2016 May 16. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375040 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1945-7170 (Electronic) Linking ISSN: 00137227 NLM ISO Abbreviation: Endocrinology Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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