Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics.

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Title: Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics.
Authors: Robles EF; Division of Hemato-Oncology, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, Pamplona 31008, Spain., Mena-Varas M; Division of Hemato-Oncology, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, Pamplona 31008, Spain., Barrio L; Department of Immunology and Oncology, Centro Nacional de Biotecnología (CNB)-CSIC, Madrid 28049, Spain., Merino-Cortes SV; Department of Immunology and Oncology, Centro Nacional de Biotecnología (CNB)-CSIC, Madrid 28049, Spain., Balogh P; Department of Immunology and Biotechnology, Szentágothai Research Center, University of Pécs, Pécs H-7624, Hungary., Du MQ; Division of Molecular Histopathology, Department of Pathology, Cambridge University, Cambridge CB2 1QP, UK., Akasaka T; MRC Toxicology Unit and Ernest and Helen Scott Haematological Research Institute, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE2 7LX, UK., Parker A; Department of Haematology, Royal Bournemouth Hospital, Bournemouth BH7 7DW, UK., Roa S; Division of Hemato-Oncology, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, Pamplona 31008, Spain., Panizo C; Department of Hematology, Clinica Universidad de Navarra, IDISNA, Pamplona 31008, Spain., Martin-Guerrero I; Institute of Human Genetics, Christian-Albrechts-University Kiel &University Hospital Schleswig-Holstein, Campus Kiel, Kiel 24105, Germany., Siebert R; Institute of Human Genetics, Christian-Albrechts-University Kiel &University Hospital Schleswig-Holstein, Campus Kiel, Kiel 24105, Germany., Segura V; Bio-informatic Unit, Department of Genomics and Proteomics, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, Pamplona 31008, Spain., Agirre X; Division of Hemato-Oncology, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, Pamplona 31008, Spain., Macri-Pellizeri L; Division of Hemato-Oncology, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, Pamplona 31008, Spain., Aldaz B; Division of Hemato-Oncology, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, Pamplona 31008, Spain., Vilas-Zornoza A; Division of Hemato-Oncology, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, Pamplona 31008, Spain., Zhang S; Division of Molecular Histopathology, Department of Pathology, Cambridge University, Cambridge CB2 1QP, UK., Moody S; Division of Molecular Histopathology, Department of Pathology, Cambridge University, Cambridge CB2 1QP, UK., Calasanz MJ; Department of Genetics, School of Medicine, University of Navarra, IDISNA, Pamplona 31008, Spain., Tousseyn T; Centre for Translation Cell and Tissue Research, KU Leuven, Leuven 3000, Belgium., Broccardo C; Department of Pathology, Institut Universitaire du Cancer de Toulouse-Oncopole, Labex TOUCAN and CRCT INSERM U1037, Toulouse F-31053, France., Brousset P; Department of Pathology, Institut Universitaire du Cancer de Toulouse-Oncopole, Labex TOUCAN and CRCT INSERM U1037, Toulouse F-31053, France., Campos-Sanchez E; Centro de Biologia Molecular Severo Ochoa, CSIC/Universidad Autonoma, Madrid 28049, Spain., Cobaleda C; Centro de Biologia Molecular Severo Ochoa, CSIC/Universidad Autonoma, Madrid 28049, Spain., Sanchez-Garcia I; Experimental Therapeutics and Translational Oncology Program, Institute of Molecular and Cellular Biology of Cancer, CSIC/University of Salamanca; and Institute of Biomedical Research of Salamanca (IBSAL), Salamanca 37007, Spain., Fernandez-Luna JL; Molecular Genetics Unit, University Hospital Marques de Valdecilla and IFIMAV, Santander 39011, Spain., Garcia-Muñoz R; Hematology Department, Hospital San Pedro, Logroño, 26006, La Rioja, Spain., Pena E; Department of Hematology, Complejo Hospitalario de Navarra, Servicio Navarro de Salud, IDISNA, Pamplona 31008, Spain., Bellosillo B; Department of Pathology, Cancer Research Program, Institut Municipal d'Investigacions Mèdiques (IMIM), Hospital del Mar, Barcelona 08003, Spain., Salar A; Department of Clinical Hematology, Cancer Research Program, Institut Municipal d'Investigacions Mèdiques (IMIM), Hospital del Mar, Barcelona 08003, Spain., Baptista MJ; Department of Hematology, ICO-Hospital Universitari Germans Trias i Pujol, Josep Carreras Leukaemia Research Institute, Universitat Autònoma de Barcelona, Badalona 08916, Spain., Hernandez-Rivas JM; Department of Hematology, IBSAL-University Hospital and IBMCC-CSIC, University of Salamanca, Salamanca 37007, Spain., Gonzalez M; Department of Hematology, IBSAL-University Hospital and IBMCC-CSIC, University of Salamanca, Salamanca 37007, Spain., Terol MJ; Department of Hematology, Hospital Clinico, INCLIVA Biomedical Research Institute, University of Valencia, Valencia 46010, Spain., Climent J; Department of Hematology, Hospital Clinico, INCLIVA Biomedical Research Institute, University of Valencia, Valencia 46010, Spain., Ferrandez A; Department of Pathology, Hospital Clinico, University of Valencia, Valencia 46010, Spain., Sagaert X; Centre for Translation Cell and Tissue Research, KU Leuven, Leuven 3000, Belgium., Melnick AM; Department of Medicine/Hematology-Oncology, Weill Cornell Medical College, New York, New York 10065, USA., Prosper F; Division of Hemato-Oncology, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, Pamplona 31008, Spain.; Department of Hematology, Clinica Universidad de Navarra, IDISNA, Pamplona 31008, Spain., Oscier DG; Department of Haematology, Royal Bournemouth Hospital, Bournemouth BH7 7DW, UK., Carrasco YR; Department of Immunology and Oncology, Centro Nacional de Biotecnología (CNB)-CSIC, Madrid 28049, Spain., Dyer MJ; MRC Toxicology Unit and Ernest and Helen Scott Haematological Research Institute, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE2 7LX, UK., Martinez-Climent JA; Division of Hemato-Oncology, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, Pamplona 31008, Spain.
Source: Nature communications [Nat Commun] 2016 Jun 14; Vol. 7, pp. 11889. Date of Electronic Publication: 2016 Jun 14.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/ncomms11889