Methylphenidate-triggered ROS generation promotes caveolae-mediated transcytosis via Rac1 signaling and c-Src-dependent caveolin-1 phosphorylation in human brain endothelial cells.
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| Title: | Methylphenidate-triggered ROS generation promotes caveolae-mediated transcytosis via Rac1 signaling and c-Src-dependent caveolin-1 phosphorylation in human brain endothelial cells. |
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| Authors: | Coelho-Santos V; Institute of Pharmacology and Experimental Therapeutics, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.; CNC.IBILI, University of Coimbra, Coimbra, Portugal., Socodato R; Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, Portugal.; Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal., Portugal C; Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, Portugal.; Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal., Leitão RA; Institute of Pharmacology and Experimental Therapeutics, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.; CNC.IBILI, University of Coimbra, Coimbra, Portugal., Rito M; Neurosurgery Service, Coimbra Hospital and University Centre (CHUC), Coimbra, Portugal., Barbosa M; Neurosurgery Service, Coimbra Hospital and University Centre (CHUC), Coimbra, Portugal.; Faculty of Medicine, University of Coimbra, Coimbra, Portugal., Couraud PO; Institut Cochin, INSERM U1016, CNRS UMR8104, Université Paris Descartes, Sorbonne Paris Cité, Paris, France., Romero IA; Department of Life Sciences, Faculty of Science, The Open University, Milton Keynes, UK., Weksler B; Department of Medicine, Weill Medical College of Cornell University, New York, NY, USA., Minshall RD; Department of Anesthesiology, University of Illinois at Chicago, Chicago, IL, USA.; Department of Pharmacology, University of Illinois at Chicago, Chicago, IL, USA., Fontes-Ribeiro C; Institute of Pharmacology and Experimental Therapeutics, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.; CNC.IBILI, University of Coimbra, Coimbra, Portugal., Summavielle T; Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, Portugal.; Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal., Relvas JB; Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, Portugal.; Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal., Silva AP; Institute of Pharmacology and Experimental Therapeutics, Faculty of Medicine, University of Coimbra, Coimbra, Portugal. apmartins@fmed.uc.pt.; CNC.IBILI, University of Coimbra, Coimbra, Portugal. apmartins@fmed.uc.pt. |
| Source: | Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2016 Dec; Vol. 73 (24), pp. 4701-4716. Date of Electronic Publication: 2016 Jul 04. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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